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    ND-B14.5A NADH dehydrogenase (ubiquinone) B14.5 A subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B14.5Aprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B14.5 A subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025839
    Locus tag
    Dmel_CG3621
    See related
    AllianceGenome:FB:FBgn0025839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152A3.7; anon-2D; anon-2Db; BcDNA:RE75088; CG3621; Dmel\CG3621; dNDUFA7; dNDUFA7A; EG:152A3.7; N4AM; NDUFA7; RNAA
    Summary
    Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B14.5A in Genome Data Viewer
    Location:
    2D6-2E1; 1-0.6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2172526..2173432)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2066559..2067465)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop Neighboring gene antisense RNA:CR45479 Neighboring gene Cytochrome P450 4d14 Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Zid BM, et al. Cell, 2009 Oct 2. PMID 19804760, Free PMC Article
    2. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
    3. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. Gandhi R, et al. DNA Cell Biol, 1992 Jun. PMID 1605861
    4. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
    5. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. Yin S, et al. PLoS One, 2013. PMID 24069262, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B14.5 A subunit
    Names
    CG3621-PA
    CG3621-PB
    FBpp0070370
    NADH ubiquinone oxidoreductase B14.5A
    NADH-ubiquinone oxidoreductase subunit B14.5a
    NADH:ubiquinone oxidoreductase B14.5A subunit
    ND-B14.5A-PA
    ND-B14.5A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2172526..2173432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297876.1 → NP_001284805.1  NADH dehydrogenase (ubiquinone) B14.5 A subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97418, Q8SYB3
      Conserved Domains (1) summary
      pfam07347
      Location:9 → 99
      CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

    2. NM_130628.4 → NP_569984.2  NADH dehydrogenase (ubiquinone) B14.5 A subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569984.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97418, Q8SYB3
      Related
      FBpp0070370
      Conserved Domains (1) summary
      pfam07347
      Location:9 → 99
      CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97418 O97418
    Q8SYB3 Q8SYB3

    Gene LinkOut

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