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    Ubc10 Ubiquitin conjugating enzyme 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubc10provided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0026316
    Locus tag
    Dmel_CG5788
    See related
    AllianceGenome:FB:FBgn0026316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5788; Dmel\CG5788; EG:52C10.4; ubc; ubcD10; UbcD10
    Summary
    Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in protein linear polyubiquitination. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to several human genes including UBE2L3 (ubiquitin conjugating enzyme E2 L3) and UBE2L5 (ubiquitin conjugating enzyme E2 L5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubc10 in Genome Data Viewer
    Location:
    54E9-54E9; 2-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17788412..17789410, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13675917..13676915, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fab1 kinase Neighboring gene mir-31a stem loop Neighboring gene adrift Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45270 Neighboring gene Double hit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS. Englund C, et al. Development, 1999 Apr. PMID 10068643
    2. Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. Asaoka T, et al. EMBO Rep, 2016 Nov. PMID 27702987, Free PMC Article
    3. Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Tan KL, et al. Dev Cell, 2018 Apr 23. PMID 29689197, Free PMC Article
    4. Occurrence of a putative SCF ubiquitin ligase complex in Drosophila. Bocca SN, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500045
    5. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein linear polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 10
    Names
    CG5788-PA
    Ubc10-PA
    NP_477414.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17788412..17789410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058066.4 → NP_477414.1  ubiquitin conjugating enzyme 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K738
      Related
      FBpp0088522
      Conserved Domains (1) summary
      pfam00179
      Location:6 → 144
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K738.1 Q7K738

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