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    CstF64 Cleavage stimulation factor 64 kD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CstF64provided by FlyBase
    Official Full Name
    Cleavage stimulation factor 64 kD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027841
    Locus tag
    Dmel_CG7697
    See related
    AllianceGenome:FB:FBgn0027841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7697; CstF 64; CStF 64; CstF-64; dCstF64; Dmel\CG7697
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Part of mRNA cleavage stimulating factor complex. Is expressed in organism. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to several human genes including CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CstF64 in Genome Data Viewer
    Location:
    91B8-91B8; 3-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18659618..18661126)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14485340..14486848)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cleavage and polyadenylation specificity factor 73 Neighboring gene uncharacterized protein Neighboring gene Golgi SNARE, 28 kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif. Salisbury J, et al. BMC Genomics, 2006 Mar 16. PMID 16542450, Free PMC Article
    2. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Soller M, et al. Genes Dev, 2003 Oct 15. PMID 14522950, Free PMC Article
    3. The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. Hatton LS, et al. Nucleic Acids Res, 2000 Jan 15. PMID 10606651, Free PMC Article
    4. Drosophila Sex-lethal protein mediates polyadenylation switching in the female germline. Gawande B, et al. EMBO J, 2006 Mar 22. PMID 16511567, Free PMC Article
    5. A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage. Gallicchio L, et al. Genes Dev, 2024 Aug 20. PMID 39111825,

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage stimulating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage stimulation factor 64 kD subunit
    Names
    CG7697-PA
    CstF64-PA
    cleavage stimulation factor
    cleavage stimulation factor 64 kilodalton subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18659618..18661126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058105.5 → NP_477453.1  cleavage stimulation factor 64 kD subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NL1, Q9U4J2, Q9VE52
      Related
      FBpp0083075
      Conserved Domains (4) summary
      COG0724
      Location:13 → 112
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12671
      Location:18 → 92
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:377 → 416
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:112 → 190
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NL1 Q86NL1
    Q9VE52 Q9VE52

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