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    Gpo3 Glycerophosphate oxidase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpo3provided by FlyBase
    Official Full Name
    Glycerophosphate oxidase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028848
    Locus tag
    Dmel_CG7311
    See related
    AllianceGenome:FB:FBgn0028848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-GPO; BG:DS08249.2; CG7311; Dmel\CG7311; Gpo; GPO; gpo-3; GPO-3
    Summary
    Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpo3 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13708215..13710583)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13708215..13710583)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44726 Neighboring gene uncharacterized protein Neighboring gene Dpr-interacting protein kappa Neighboring gene uncharacterized protein Neighboring gene nemuri

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic and molecular analysis of the alpha glycerophosphate cycle in Drosophila melanogaster. MacIntyre RJ, et al. Isozymes Curr Top Biol Med Res, 1987. PMID 3110096
    2. The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. O'Brien SJ, et al. Biochem Genet, 1972 Oct. PMID 4340553
    3. Regulation of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster larvae by dietary ethanol and sucrose. Geer BW, et al. J Nutr, 1983 Aug. PMID 6410023
    4. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Lemos B, et al. Science, 2008 Jan 4. PMID 18174442
    5. The biological basis of ethanol tolerance in Drosophila. Geer BW, et al. Comp Biochem Physiol B, 1993 Jun. PMID 8359013

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphate oxidase 3
    Names
    CG7311-PD
    CG7311-PE
    Gpo3-PD
    Gpo3-PE
    alpha glycerophosphate oxidase 3
    NP_001246023.1
    NP_609667.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13708215..13710583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135823.3 → NP_609667.2  glycerophosphate oxidase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609667.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTA9, Q8MR87
      Conserved Domains (2) summary
      COG0578
      Location:7 → 554
      GlpA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]
      pfam16901
      Location:417 → 537
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

    2. NM_001259094.2 → NP_001246023.1  glycerophosphate oxidase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF20
      Conserved Domains (1) summary
      PLN02464
      Location:3 → 127
      PLN02464; glycerol-3-phosphate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF20 M9NF20
    Q7KTA9 Q7KTA9
    Q8IHF5 Q8IHF5
    Q8MR87 Q8MR87

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