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    CG14443 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14443provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029880
    Locus tag
    Dmel_CG14443
    See related
    AllianceGenome:FB:FBgn0029880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg14443; Dmel\CG14443
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14443 in Genome Data Viewer
    Location:
    6C2-6C2; 1-18 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6633959..6636169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6527992..6530202)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43832 Neighboring gene Protein interacting with APP tail-1 Neighboring gene Anaphase Promoting Complex subunit 7 Neighboring gene pickled eggs Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Deddouche S, et al. Nat Immunol, 2008 Dec. PMID 18953338
    2. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article
    3. The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Pines MK, et al. Development, 2010 Mar. PMID 20150280, Free PMC Article
    4. RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases. Ulvila J, et al. Scand J Immunol, 2010 Mar. PMID 20415780
    5. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2015 Jul 21. PMID 26199285, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14443-PB
    NP_572330.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6633959..6636169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132102.2 → NP_572330.2  uncharacterized protein Dmel_CG14443 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572330.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W3Y5
      Conserved Domains (3) summary
      smart00487
      Location:345 → 544
      DEXDc; DEAD-like helicases superfamily
      pfam00271
      Location:560 → 670
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:332 → 535
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3Y5.2 Q9W3Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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