inaE inactivation no afterpotential E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: inaEprovided by FlyBase
Official Full Name: inactivation no afterpotential Eprovided by FlyBase
Primary source: FLYBASE:FBgn0261244
Locus tag: Dmel_CG33174
See related: AllianceGenome:FB:FBgn0261244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11096; CG11102; CG11104; CG15761; CG32630; CG33174; DAGL; DAGL/inaE; dDAGL; Dmel\CG33174; EP(X)1101; INAE
Summary: Enables lipoprotein lipase activity. Involved in phototransduction and response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including adult head; calyx of adult mushroom body; embryonic dorsal epidermis; embryonic head epidermis; and ganglia. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12C4-12C5; 1-46 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13783714..13811493)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13677747..13705526)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Drosophila and Caenorhabditis elegans, overexpression of diacylglycerol lipase (DAGL/inaE/dagl-1) or knockdown of diacylglycerol kinase (DGK/rdgA/dgk-5) extends lifespan and enhances response to oxidative stress.
Title: Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2030 (e-PCR)
- UniSTS:515474

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein lipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inactivation no afterpotential E

Names: CG33174-PA; CG33174-PD; CG33174-PE; CG33174-PF; CG33174-PG; CG33174-PH; CG33174-PI; diacylglycerol lipase; inaE-PA; inaE-PD; inaE-PE; inaE-PF; inaE-PG; inaE-PH; inaE-PI

NP_001138195.1

EC 3.1.1.34

NP_001138196.1

EC 3.1.1.34

NP_001285230.1

EC 3.1.1.34

NP_001285231.1

EC 3.1.1.34

NP_001401060.1

EC 3.1.1.34

NP_788900.1

EC 3.1.1.34

NP_788901.1

EC 3.1.1.34

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13783714..13811493

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144724.2 → NP_001138196.1 inactivation no afterpotential E, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138196.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z151

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001144723.2 → NP_001138195.1 inactivation no afterpotential E, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138195.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z150

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001298302.1 → NP_001285231.1 inactivation no afterpotential E, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285231.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JDP4

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001298301.1 → NP_001285230.1 inactivation no afterpotential E, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285230.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JBS2

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_176727.3 → NP_788900.1 inactivation no afterpotential E, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788900.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86B55

Related

FBpp0073656

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_176728.3 → NP_788901.1 inactivation no afterpotential E, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788901.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MR12

Related

FBpp0073657

Conserved Domains (1) summary

cd00519
Location:300 → 542

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001414079.1 → NP_001401060.1 inactivation no afterpotential E, isoform I [Drosophila melanogaster]

Status: REVIEWED