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    CG42346 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42346provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259677
    Locus tag
    Dmel_CG42346
    See related
    AllianceGenome:FB:FBgn0259677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40500; CG40500-PA; CG41105; Dmel\CG42346
    Old locus tag
    Dmel_CG40500; Dmel_CG41105
    Summary
    Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; and primary immunodeficiency disease (multiple). Orthologous to several human genes including IGFALS (insulin like growth factor binding protein acid labile subunit); NRROS (negative regulator of reactive oxygen species); and TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42346 in Genome Data Viewer
    Location:
    20E2-20F1; 1-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22832399..22885541)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22234235..22287377)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45464 Neighboring gene uncharacterized protein Neighboring gene mir-2491 stem loop Neighboring gene folded gastrulation Neighboring gene long non-coding RNA:CR43656 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR41352 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Bergman CM, et al. Genome Biol, 2006. PMID 17134480, Free PMC Article
    2. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Swanson LE, et al. Genetics, 2009 Apr. PMID 19171940, Free PMC Article
    3. Genome ARTIST_v2-An Autonomous Bioinformatics Tool for Annotation of Natural Transposons in Sequenced Genomes. Ecovoiu AA, et al. Int J Mol Sci, 2022 Oct 21. PMID 36293549, Free PMC Article
    4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    5. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 22838038-22838552 mobile_element_type = transposon:INE-1{}3613
    • Loc: 22841928-22843500 mobile_element_type = transposon:HB{}276
    • Loc: 22875600-22875928 mobile_element_type = transposon:INE-1{}3787
    • Loc: 22882039-22883543 mobile_element_type = transposon:HB{}4413

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42346-PC
    CG42346-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22832399..22885541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042838.2 → NP_001036303.2  uncharacterized protein Dmel_CG42346, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036303.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHN6
      Conserved Domains (4) summary
      cd00116
      Location:804 → 1076
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:725 → 736
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:534 → 556
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:1163 → 1219
      LRR_8; Leucine rich repeat

    2. NM_001042841.4 → NP_001036306.3  uncharacterized protein Dmel_CG42346, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036306.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHN6
      Conserved Domains (4) summary
      cd00116
      Location:804 → 1076
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:725 → 736
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:534 → 556
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:1163 → 1219
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHN6 Q0KHN6

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