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    CG40485 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG40485provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0069973
    Locus tag
    Dmel_CG40485
    See related
    AllianceGenome:FB:FBgn0069973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG40485; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult fat body and adult head. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG40485 in Genome Data Viewer
    Location:
    20F3-20F3; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22960609..22962360, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22362445..22364196, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45502 Neighboring gene uncharacterized protein Neighboring gene stoned A Neighboring gene stoned B Neighboring gene antisense RNA:CR45009 Neighboring gene alpha1,3-fucosyltransferase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
    2. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Bergman CM, et al. Genome Biol, 2006. PMID 17134480, Free PMC Article
    3. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
    4. A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome. Yandell M, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15668397, Free PMC Article
    5. The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation. Ou Q, et al. Cell Rep, 2016 Jun 28. PMID 27320926, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG40485-PA
    CG40485-PB
    CG40485-PC
    NP_001036313.1
    NP_001036314.1
    NP_001303574.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22960609..22962360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042848.2 → NP_001036313.1  uncharacterized protein Dmel_CG40485, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNV7
      Conserved Domains (2) summary
      COG4221
      Location:1 → 247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001316645.1 → NP_001303574.1  uncharacterized protein Dmel_CG40485, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNV7
      Conserved Domains (2) summary
      COG4221
      Location:1 → 247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001042849.2 → NP_001036314.1  uncharacterized protein Dmel_CG40485, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3F5, Q5LJT0
      Conserved Domains (1) summary
      cl21454
      Location:1 → 192
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5LJT0 Q5LJT0
    Q6NNV7 Q6NNV7

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