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    Creld Cysteine rich with EGF like domains [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Creldprovided by FlyBase
    Official Full Name
    Cysteine rich with EGF like domainsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031217
    Locus tag
    Dmel_CG11377
    See related
    AllianceGenome:FB:FBgn0031217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11377; CT31762; Dmel\CG11377
    Summary
    Predicted to enable calcium ion binding activity. Involved in mitochondrion organization. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in adult head. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1) and CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Creld in Genome Data Viewer
    Location:
    21B2-21B2; 2-0.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (102380..104142)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (102380..104142)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene net Neighboring gene Zizimin-related Neighboring gene Na[+]/H[+] hydrogen exchanger 1 Neighboring gene S-adenosylmethionine Synthetase Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Paradis M, et al. Sci Adv, 2022 Jul 22. PMID 35867795, Free PMC Article
    2. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
    3. Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family. Giannakou ME, et al. J Exp Biol, 2001 Nov. PMID 11719534
    4. A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions. Kolkhof P, et al. Mol Cell Proteomics, 2017 Mar. PMID 27956707, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine rich with EGF like domains
    Names
    CG11377-PA
    CG11377-PB
    Creld-PA
    Creld-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      102380..104142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134646.4 → NP_608490.1  cysteine rich with EGF like domains, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPJ0
      Related
      FBpp0077763
      Conserved Domains (3) summary
      smart00179
      Location:231 → 259
      EGF_CA; Calcium-binding EGF-like domain
      smart00261
      Location:258 → 293
      FU; Furin-like repeats
      pfam11938
      Location:31 → 123
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    2. NM_001272861.1 → NP_001259790.1  cysteine rich with EGF like domains, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDP6
      Conserved Domains (2) summary
      smart00261
      Location:258 → 292
      FU; Furin-like repeats
      pfam11938
      Location:31 → 123
      DUF3456; TLR4 regulator and MIR-interacting MSAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDP6 M9PDP6
    Q9VPJ0 Q9VPJ0

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