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    Gr28b Gustatory receptor 28b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gr28bprovided by FlyBase
    Official Full Name
    Gustatory receptor 28bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045495
    Locus tag
    Dmel_CG13788
    See related
    AllianceGenome:FB:FBgn0045495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    28A3; CG13788; Dmel\CG13788; Gr28A3; Gr28A4; gr28b; GR28b; GR28B; Gr28b(D); GR28B(D); Gr28b.a; Gr28b.b; Gr28b.c; Gr28b.d; Gr28b.e; Gr28bA; Gr28bB; Gr28bC; Gr28bD; Gr28be; Gr28bE; GRLU.2; GrLU2; LU.2
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity and taste receptor activity. Involved in several processes, including defense response to other organism; negative phototaxis; and thermosensory behavior. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in several structures, including adult sense organ; ganglia; neurosecretory neurons; organism subdivision; and sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gr28b in Genome Data Viewer
    Location:
    28A1-28A1; 2-27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7454826..7462247, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7454826..7462247, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene scavenger receptor acting in neural tissue and majority of rhodopsin is absent Neighboring gene Gustatory receptor 28a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Zizimin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Gr28bD product is a non-specific cation channel that can be used as a novel thermogenetic tool. Mishra A, et al. Sci Rep, 2018 Jan 17. PMID 29343813, Free PMC Article
    2. Antennae sense heat stress to inhibit mating and promote escaping in Drosophila females. Miwa Y, et al. J Neurogenet, 2018 Dec. PMID 30231794
    3. Dopaminergic neurons can influence heat-box place learning in Drosophila. Mishra A, et al. J Neurogenet, 2020 Mar. PMID 31997669
    4. Nutrient-dependent increased dendritic arborization of somatosensory neurons. Watanabe K, et al. Genes Cells, 2017 Jan. PMID 27868313
    5. Thermosensory perception regulates speed of movement in response to temperature changes in Drosophila melanogaster. Soto-Padilla A, et al. J Exp Biol, 2018 May 22. PMID 29650755

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables taste receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables taste receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemosensory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of taste ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    gustatory receptor 28b
    Names
    CG13788-PA
    CG13788-PB
    CG13788-PC
    CG13788-PD
    CG13788-PE
    Gr28b-PA
    Gr28b-PB
    Gr28b-PC
    Gr28b-PD
    Gr28b-PE
    gustatory receptor 28A4
    gustatory receptor LU.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7454826..7462247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139357.4 → NP_647614.2  gustatory receptor 28b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647614.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM08
      Related
      FBpp0079086
      Conserved Domains (1) summary
      pfam08395
      Location:29 → 425
      7tm_7; 7tm Chemosensory receptor

    2. NM_205921.3 → NP_995643.1  gustatory receptor 28b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q059D1
      Conserved Domains (1) summary
      pfam08395
      Location:20 → 416
      7tm_7; 7tm Chemosensory receptor

    3. NM_205920.3 → NP_995642.1  gustatory receptor 28b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM08
      Conserved Domains (1) summary
      pfam08395
      Location:45 → 443
      7tm_7; 7tm Chemosensory receptor

    4. NM_205919.3 → NP_995641.1  gustatory receptor 28b, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM08
      Conserved Domains (1) summary
      pfam08395
      Location:42 → 413
      7tm_7; 7tm Chemosensory receptor

    5. NM_205918.3 → NP_995640.1  gustatory receptor 28b, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM08
      Conserved Domains (1) summary
      pfam08395
      Location:23 → 420
      7tm_7; 7tm Chemosensory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM08.2 Q9VM08

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