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    CG8349 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8349provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032003
    Locus tag
    Dmel_CG8349
    See related
    AllianceGenome:FB:FBgn0032003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8349
    Summary
    Predicted to enable cytidine deaminase activity and zinc ion binding activity. Predicted to be involved in cytidine deamination. Predicted to be active in cytosol. Is expressed in primary spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8349 in Genome Data Viewer
    Location:
    28F3-28F3; 2-30 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8215915..8216901)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8215915..8216901)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 6 Neighboring gene PDGF- and VEGF-receptor related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of transcription of meiotic cell cycle and terminal differentiation genes by the testis-specific Zn-finger protein matotopetli. Perezgasga L, et al. Development, 2004 Apr. PMID 15084455
    2. A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7. Zahoor MK, et al. Mol Genet Genomics, 2019 Jun. PMID 30656413
    3. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article
    4. Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. Esslinger SM, et al. RNA Biol, 2013 Jun. PMID 23669073, Free PMC Article
    5. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8349-PA
    NP_609197.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8215915..8216901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135353.3 → NP_609197.2  uncharacterized protein Dmel_CG8349 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609197.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTJ2, Q8T8Y3, Q9VLR1
      Related
      FBpp0079215
      Conserved Domains (2) summary
      COG0295
      Location:122 → 260
      Cdd; Cytidine deaminase [Nucleotide transport and metabolism]
      cl00269
      Location:125 → 260
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTJ2 Q7KTJ2
    Q8T8Y3 Q8T8Y3

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