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    CG17568 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17568provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032763
    Locus tag
    Dmel_CG17568
    See related
    AllianceGenome:FB:FBgn0032763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17568
    Summary
    Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17568 in Genome Data Viewer
    Location:
    37C6-37C6; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19179749..19181702, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19179749..19181702, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynactin 6, p27 subunit Neighboring gene RNA polymerase I and III subunit D Neighboring gene brain tumor Neighboring gene long non-coding RNA:CR44977 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Chen LY, et al. Curr Biol, 2006 Jun 20. PMID 16782008
    2. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
    3. Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila. Bonchuk A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33638995, Free PMC Article
    4. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article
    5. Genes Relocated Between Drosophila Chromosome Arms Evolve Under Relaxed Selective Constraints Relative to Non-Relocated Genes. Hart MLI, et al. J Mol Evol, 2018 Jul. PMID 29926120

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17568-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19179749..19181702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136107.2 → NP_609951.2  uncharacterized protein Dmel_CG17568 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609951.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6X8, Q9VIY9
      Conserved Domains (4) summary
      smart00868
      Location:10 → 87
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5048
      Location:313 → 471
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:398 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:439 → 463
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIY9 Q9VIY9

    Gene LinkOut

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