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    Dus3 Dihydrouridine synthase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dus3provided by FlyBase
    Official Full Name
    Dihydrouridine synthase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032819
    Locus tag
    Dmel_CG10463
    See related
    AllianceGenome:FB:FBgn0032819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10463; Dmel\CG10463
    Summary
    Predicted to enable tRNA-dihydrouridine47 synthase activity. Predicted to be involved in tRNA processing. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dus3 in Genome Data Viewer
    Location:
    38A2-38A2; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19758879..19760986)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19758879..19760986)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fructose-1,6-bisphosphatase Neighboring gene brain-specific homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
    2. Transcriptional regionalization of the fruit fly's airway epithelium. Faisal MN, et al. PLoS One, 2014. PMID 25020150, Free PMC Article
    3. Oviposition behaviour in Drosophila melanogaster: Genetic and behavioural decoupling between oviposition acceptance and preference for natural fruits. Fanara JJ, et al. J Evol Biol, 2023 Jan. PMID 36357966
    4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine47 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dihydrouridine synthase 3
    Names
    CG10463-PA
    Dus3-PA
    NP_610000.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19758879..19760986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136156.1 → NP_610000.1  dihydrouridine synthase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRT5, Q9VIS4
      Related
      FBpp0080828, FBtr0081290
      Conserved Domains (2) summary
      COG0042
      Location:253 → 547
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:258 → 492
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRT5 Q8MRT5
    Q9VIS4 Q9VIS4

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