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    CG13743 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13743provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033368
    Locus tag
    Dmel_CG13743
    See related
    AllianceGenome:FB:FBgn0033368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13743
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be active in membrane. Is expressed in adult abdomen; adult head; and adult thorax. Orthologous to human SLC38A11 (solute carrier family 38 member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13743 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9044850..9060608, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4932355..4948113, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ance-4 Neighboring gene Prophenoloxidase 2 Neighboring gene uncharacterized protein Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of SLC38 Transporter Ortholog - CG13743 Reveals a Metabolic Relevance in Drosophila. Aggarwal T, et al. Front Physiol, 2019. PMID 32038282, Free PMC Article
    2. Prophenoloxidase activation is required for survival to microbial infections in Drosophila. Binggeli O, et al. PLoS Pathog, 2014 May. PMID 24788090, Free PMC Article
    3. Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, et al. Neurobiol Dis, 2017 Nov. PMID 28237316
    4. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2017 Aug 14. PMID 28806173, Free PMC Article
    5. A post-ingestive amino acid sensor promotes food consumption in Drosophila. Yang Z, et al. Cell Res, 2018 Oct. PMID 30209352, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13743-PA
    CG13743-PB
    CG13743-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9044850..9060608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299295.1 → NP_001286224.1  uncharacterized protein Dmel_CG13743, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEY7
      Conserved Domains (1) summary
      cl00456
      Location:75 → 245
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001259285.2 → NP_001246214.1  uncharacterized protein Dmel_CG13743, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7V2
      Conserved Domains (1) summary
      cl00456
      Location:75 → 480
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_136600.2 → NP_610444.2  uncharacterized protein Dmel_CG13743, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610444.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRD1, Q9V522
      Related
      FBpp0087743
      Conserved Domains (2) summary
      COG0814
      Location:95 → 491
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:95 → 500
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7V2 A0A0B4K7V2
    A0A0B4LEY7 A0A0B4LEY7
    Q8MRD1 Q8MRD1

    Gene LinkOut

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