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    lectin-46Cb lectin-46Cb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lectin-46Cbprovided by FlyBase
    Official Full Name
    lectin-46Cbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040092
    Locus tag
    Dmel_CG1652
    See related
    AllianceGenome:FB:FBgn0040092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 007330B; AC007330b; CG1652; Dmel\CG1652; Lectin-46Cb; lectin46Cb
    Summary
    Predicted to enable galactose binding activity. Involved in protein localization; regulation of female receptivity, post-mating; and sperm competition. Located in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CLEC4F (C-type lectin domain family 4 member F) and CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lectin-46Cb in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9815510..9816600)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5703015..5704105)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44208 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lectin-46Ca Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex peptide is required for the efficient release of stored sperm in mated Drosophila females. Avila FW, et al. Genetics, 2010 Oct. PMID 20679516, Free PMC Article
    2. A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila. Ram KR, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706411, Free PMC Article
    3. The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility. Maeda RK, et al. PLoS Genet, 2018 Jul. PMID 30011265, Free PMC Article
    4. Acp36DE is required for uterine conformational changes in mated Drosophila females. Avila FW, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19805225, Free PMC Article
    5. Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females. Misra S, et al. Elife, 2020 Jul 16. PMID 32672537, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables galactose binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sperm competition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lectin-46Cb
    Names
    CG1652-PB
    lectin 46cb
    lectin-46Cb-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9815510..9816600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169631.1 → NP_001163102.1  lectin-46Cb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JY62
      Conserved Domains (1) summary
      cd00037
      Location:38 → 155
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JY62 Q7JY62

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