unc-104 uncoordinated-104 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: unc-104provided by FlyBase
Official Full Name: uncoordinated-104provided by FlyBase
Primary source: FLYBASE:FBgn0267002
Locus tag: Dmel_CG8566
See related: AllianceGenome:FB:FBgn0267002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bris; CG8566; DmCG8566; DmDUnc104; Dmel\CG8566; DmKlp53D; DUnc-104; Dunc104; DUNC104; imac; Imac; KIF 1B; kif1a; Kif1a; KIF1A; KIF1A/1B; Klp53D; Unc-104; unc104; Unc104
Summary: Enables GTP-dependent protein binding activity. Involved in several processes, including anterograde synaptic vesicle transport; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of insulin secretion. Located in axon terminus and dendrite. Part of microtubule associated complex. Is expressed in adult head and larval central nervous system. Used to study nervous system disease. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2A1; NESCAV syndrome; carcinoma (multiple); hereditary sensory neuropathy (multiple); and hereditary spastic paraplegia (multiple). Orthologous to several human genes including KIF1A (kinesin family member 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53D6-53D8; 2-80 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16751503..16772671, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12639008..12660176, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prd1, alpha-Adaptin, and Unc-104 act in a common pathway to promote dendrite pruning by down-regulating Neuroglian protein.
Title: Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.
provide novel insights into the role of Unc-104 in synapse maturation
Title: The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization.
These studies at the Drosophila neuromuscular junction indicate that many synaptic defects in unc-104-null mutants are mediated independently of Unc-104's transport function, via the Wallenda (Wnd)/DLK MAP kinase axonal damage signaling pathway.
Title: Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104.
Unc-104 critically restricts neuromuscular junction growth and dendrite branch morphogenesis.
Title: The kinesin-3, unc-104 regulates dendrite morphogenesis and synaptic development in Drosophila.
Drosophila Unc-104 has neuronal functions that are distinct from those of the classic anterograde axonal motor, kinesin-1.
Title: Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides.
Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting.
Title: A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde neuronal dense core vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: uncoordinated-104

Names: CG8566-PB; CG8566-PC; CG8566-PD; CG8566-PE; CG8566-PF; CG8566-PG; CG8566-PH; CG8566-PI; D uncoordinated protein 104; Kinesin4B; bristly; immaculate connections; kinesin 3; kinesin-3; unc-104 ortholog; unc-104-PB; unc-104-PC; unc-104-PD; unc-104-PE; unc-104-PF; unc-104-PG; unc-104-PH; unc-104-PI; uncoordinated 104

NP_001097346.1

EC 5.6.1.3

NP_001246373.1

EC 5.6.1.3

NP_001246374.1

EC 5.6.1.3

NP_001261033.1

EC 5.6.1.3

NP_001303353.1

EC 5.6.1.3

NP_611155.3

EC 5.6.1.3

NP_725607.2

EC 5.6.1.3

NP_725610.2

EC 5.6.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16751503..16772671 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166192.4 → NP_725610.2 uncoordinated-104, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725610.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZAJ2, A8DX00, A8DYG5, Q9NBL1

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:475 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1533 → 1635

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1538 → 1631

PH; PH domain

pfam12423
Location:808 → 854

KIF1B; Kinesin protein 1B

pfam12473
Location:1177 → 1278

DUF3694; Kinesin protein

pfam16183
Location:355 → 498

Kinesin_assoc; Kinesin-associated
NM_001274104.2 → NP_001261033.1 uncoordinated-104, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261033.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF91

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:475 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1524 → 1626

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1529 → 1622

PH; PH domain

pfam12423
Location:808 → 854

KIF1B; Kinesin protein 1B

pfam12473
Location:1177 → 1278

DUF3694; Kinesin protein

pfam16183
Location:355 → 498

Kinesin_assoc; Kinesin-associated
NM_001316424.1 → NP_001303353.1 uncoordinated-104, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUN3

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:475 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1524 → 1626

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1529 → 1622

PH; PH domain

pfam12423
Location:808 → 854

KIF1B; Kinesin protein 1B

pfam12473
Location:1177 → 1278

DUF3694; Kinesin protein

pfam16183
Location:355 → 498

Kinesin_assoc; Kinesin-associated
NM_166190.4 → NP_725607.2 uncoordinated-104, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725607.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZAJ2, A8DX00, A8DYG5, Q9NBL1

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:475 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1533 → 1635

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1538 → 1631

PH; PH domain

pfam12423
Location:808 → 854

KIF1B; Kinesin protein 1B

pfam12473
Location:1177 → 1278

DUF3694; Kinesin protein

pfam16183
Location:355 → 498

Kinesin_assoc; Kinesin-associated
NM_137311.5 → NP_611155.3 uncoordinated-104, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611155.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZAJ2

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:475 → 574

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1602 → 1704

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1607 → 1700

PH; PH domain

pfam12423
Location:878 → 923

KIF1B; Kinesin protein 1B

pfam12473
Location:1246 → 1347

DUF3694; Kinesin protein

pfam16183
Location:355 → 498

Kinesin_assoc; Kinesin-associated
NM_001259445.2 → NP_001246374.1 uncoordinated-104, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246374.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7D4

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:489 → 588

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1544 → 1646

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1549 → 1642

PH; PH domain

pfam12423
Location:822 → 868

KIF1B; Kinesin protein 1B

pfam12473
Location:1191 → 1292

DUF3694; Kinesin protein

pfam16183
Location:355 → 512

Kinesin_assoc; Kinesin-associated
NM_001259444.2 → NP_001246373.1 uncoordinated-104, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246373.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K767

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:489 → 588

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1538 → 1640

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1543 → 1636

PH; PH domain

pfam12423
Location:822 → 868

KIF1B; Kinesin protein 1B

pfam12473
Location:1191 → 1292

DUF3694; Kinesin protein

pfam16183
Location:355 → 512

Kinesin_assoc; Kinesin-associated
NM_001103876.3 → NP_001097346.1 uncoordinated-104, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097346.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZAJ2

Conserved Domains (8) summary

smart00129
Location:3 → 358

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:489 → 588

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1547 → 1649

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:2 → 358

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1552 → 1645

PH; PH domain

pfam12423
Location:822 → 868

KIF1B; Kinesin protein 1B

pfam12473
Location:1191 → 1292

DUF3694; Kinesin protein

pfam16183
Location:355 → 512

Kinesin_assoc; Kinesin-associated