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    CG18609 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18609provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034382
    Locus tag
    Dmel_CG18609
    See related
    AllianceGenome:FB:FBgn0034382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT42569; Dmel\CG18609
    Summary
    Enables fatty acid elongase activity. Involved in cuticle hydrocarbon biosynthetic process; fatty acid elongation; and very long-chain fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; embryonic/larval oenocyte; and organism. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL7 (ELOVL fatty acid elongase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18609 in Genome Data Viewer
    Location:
    55E11-55E11; 2-86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18742517..18743626, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14630022..14631131, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene Lithium-inducible SLC6 transporter Neighboring gene long non-coding RNA:CR30121 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of a fatty acyl-CoA elongase underlies desert adaptation in Drosophila. Wang Z, et al. Sci Adv, 2023 Sep. PMID 37647401, Free PMC Article
    2. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, et al. Dev Cell, 2019 Jan 28. PMID 30554999, Free PMC Article
    3. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Gutierrez E, et al. Nature, 2007 Jan 18. PMID 17136098
    4. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
    5. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Szafer-Glusman E, et al. Curr Biol, 2008 Sep 23. PMID 18804373, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid elongase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fatty acid elongase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cuticle development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cuticle hydrocarbon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18609-PA
    NP_611365.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18742517..18743626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137521.3 → NP_611365.2  uncharacterized protein Dmel_CG18609 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611365.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN18
      Related
      FBpp0085825
      Conserved Domains (1) summary
      pfam01151
      Location:16 → 257
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NN18 Q6NN18

    Gene LinkOut

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