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    Cyp6d2 Cytochrome P450 6d2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6d2provided by FlyBase
    Official Full Name
    Cytochrome P450 6d2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034756
    Locus tag
    Dmel_CG4373
    See related
    AllianceGenome:FB:FBgn0034756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6d2; CG4373; Dmel\CG4373
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to camptothecin. Is expressed in adult head; embryonic/larval tracheal section; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6d2 in Genome Data Viewer
    Location:
    58F4-58F4; 2-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22652573..22654530, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18540078..18542035, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene novel spermatogenesis regulator Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. Thomas AM, et al. G3 (Bethesda), 2013 Jan. PMID 23316441, Free PMC Article
    2. Genome-wide expression analysis identifies a modulator of ionizing radiation-induced p53-independent apoptosis in Drosophila melanogaster. van Bergeijk P, et al. PLoS One, 2012. PMID 22666323, Free PMC Article
    3. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article
    4. Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males. Lu B, et al. Biol Open, 2014 Feb 15. PMID 24463366, Free PMC Article
    5. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
      Title: Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 6d2
    Names
    CG4373-PA
    Cyp6d2-PA
    cytochrome P450
    NP_611698.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22652573..22654530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137854.3 → NP_611698.1  cytochrome P450 6d2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W223
      Related
      FBpp0071839
      Conserved Domains (1) summary
      pfam00067
      Location:65 → 506
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W223.1 Q9W223

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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