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    Eglp4 Entomoglyceroporin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eglp4provided by FlyBase
    Official Full Name
    Entomoglyceroporin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0034885
    Locus tag
    Dmel_CG4019
    See related
    AllianceGenome:FB:FBgn0034885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aqp4019; CG4019; Dmel\CG4019; Eglp 4
    Summary
    Predicted to enable channel activity. Involved in renal system process. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult head; adult heart; apoptotic amnioserosa; embryonic anal pad; and muscle cell. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eglp4 in Genome Data Viewer
    Location:
    59F4-59F4; 2-104 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23607592..23614710, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19495115..19502233, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 1 Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 3 Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene Phosphodiesterase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Kaufmann N, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15800049
    2. Insect glycerol transporters evolved by functional co-option and gene replacement. Finn RN, et al. Nat Commun, 2015 Jul 17. PMID 26183829, Free PMC Article
    3. Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Cabrero P, et al. Proc Natl Acad Sci U S A, 2020 Jan 21. PMID 31907321, Free PMC Article
    4. Genetic mapping with SNP markers in Drosophila. Berger J, et al. Nat Genet, 2001 Dec. PMID 11726933
    5. Transporters and tubule crystals in the insect Malpighian tubule. Reynolds CJ, et al. Curr Opin Insect Sci, 2021 Oct. PMID 34044181, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in renal system process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    entomoglyceroporin 4
    Names
    CG4019-PA
    CG4019-PB
    CG4019-PC
    CG4019-PD
    CG4019-PE
    CG4019-PF
    Eglp4-PA
    Eglp4-PB
    Eglp4-PC
    Eglp4-PD
    Eglp4-PE
    Eglp4-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23607592..23614710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137969.3 → NP_611813.1  entomoglyceroporin 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR72
      Related
      FBpp0072011
      Conserved Domains (1) summary
      cl00200
      Location:11 → 224
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    2. NM_166615.3 → NP_726349.1  entomoglyceroporin 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR72
      Related
      FBpp0072012
      Conserved Domains (1) summary
      cl00200
      Location:11 → 224
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    3. NM_166614.2 → NP_726348.1  entomoglyceroporin 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR72
      Related
      FBpp0072013
      Conserved Domains (1) summary
      cl00200
      Location:11 → 224
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    4. NM_166613.2 → NP_726347.1  entomoglyceroporin 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLR2
      Related
      FBpp0072014
      Conserved Domains (1) summary
      cl00200
      Location:23 → 236
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    5. NM_001259553.1 → NP_001246482.1  entomoglyceroporin 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z394
      Conserved Domains (1) summary
      cl00200
      Location:48 → 261
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    6. NM_001274225.1 → NP_001261154.1  entomoglyceroporin 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ1
      Conserved Domains (1) summary
      cl00200
      Location:59 → 272
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ1 A0A0B4KFZ1
    D1Z394 D1Z394
    Q6NR72 Q6NR72
    Q8MLR2 Q8MLR2

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