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    CG4612 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4612provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035016
    Locus tag
    Dmel_CG4612
    See related
    AllianceGenome:FB:FBgn0035016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4612; Dmel\CG4612
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in long-term memory and positive regulation of translation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and nephrocyte. Orthologous to several human genes including PABPC4L (poly(A) binding protein cytoplasmic 4 like) and PABPC5 (poly(A) binding protein cytoplasmic 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4612 in Genome Data Viewer
    Location:
    60D3-60D4; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24521874..24526089, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20409397..20413612, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 60d Neighboring gene Ionotropic receptor 60f Neighboring gene BRCA2, DNA repair associated Neighboring gene Ionotropic receptor 60e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Making of Long-Lasting Memories: A Fruit Fly Perspective. Roselli C, et al. Front Behav Neurosci, 2021. PMID 33859556, Free PMC Article
    2. Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster. Ejima A, et al. Genetics, 2004 Dec. PMID 15611177, Free PMC Article
    3. Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. Klovstad M, et al. PLoS Genet, 2008 Feb. PMID 18266476, Free PMC Article
    4. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. Machado Almeida P, et al. Nat Commun, 2021 Oct 1. PMID 34599173, Free PMC Article
    5. Global patterns of tissue-specific alternative polyadenylation in Drosophila. Smibert P, et al. Cell Rep, 2012 Mar 29. PMID 22685694, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4612-PA
    CG4612-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24521874..24526089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259564.2 → NP_001246493.1  uncharacterized protein Dmel_CG4612, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W158
      Conserved Domains (2) summary
      cd12379
      Location:115 → 185
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:202 → 282
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins

    2. NM_138080.4 → NP_611924.1  uncharacterized protein Dmel_CG4612, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W158
      Related
      FBpp0072253
      Conserved Domains (2) summary
      cd12379
      Location:115 → 185
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:202 → 282
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W158 Q9W158

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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