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    msd1 mitotic spindle density 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    msd1provided by FlyBase
    Official Full Name
    mitotic spindle density 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035209
    Locus tag
    Dmel_CG13914
    See related
    AllianceGenome:FB:FBgn0035209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13914; Dgt9; Dmel\CG13914; Msd1
    Summary
    Involved in mitotic spindle-templated microtubule nucleation. Part of HAUS complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See msd1 in Genome Data Viewer
    Location:
    61F6-61F6; 3-0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1331744..1332326)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1331744..1332326)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myosin 61F Neighboring gene long non-coding RNA:CR45166 Neighboring gene NADH dehydrogenase (ubiquinone) acyl carrier protein Neighboring gene mitotic spindle density 5 Neighboring gene uncharacterized protein Neighboring gene Hydroxymethylbilane synthase Neighboring gene indra

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Wainman A, et al. Genes Dev, 2009 Aug 15. PMID 19684111, Free PMC Article
    2. Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation. Hayward D, et al. Dev Cell, 2014 Jan 13. PMID 24389063, Free PMC Article
    3. Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle. Chen JWC, et al. Biol Open, 2017 May 15. PMID 28351835, Free PMC Article
    4. Augmin complex activity finetunes dendrite morphology through non-centrosomal microtubule nucleation in vivo. Zhang Y, et al. J Cell Sci, 2024 May 1. PMID 38587100, Free PMC Article
    5. In vitro reconstitution of branching microtubule nucleation. Tariq A, et al. Elife, 2020 Jan 14. PMID 31933481, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the microtubule-associated protein Msd1 is a new component of the Augmin complex and is required for nucleation of microtubules from within the mitotic spindle
      Title: A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic spindle density 1
    Names
    CG13914-PA
    msd1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1331744..1332326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138256.4 → NP_612100.2  mitotic spindle density 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612100.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NMY7, Q9W0G7
      Conserved Domains (1) summary
      pfam16417
      Location:41 → 88
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0G7.2 Q9W0G7

    Gene LinkOut

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