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    mRpL46 mitochondrial ribosomal protein L46 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRpL46provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein L46provided by FlyBase
    Primary source
    FLYBASE:FBgn0035272
    Locus tag
    Dmel_CG13922
    See related
    AllianceGenome:FB:FBgn0035272
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13922; Dmel\CG13922; MRP-L46; mRpl46; MRpL46
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; larval muscle system; and trunk mesoderm. Orthologous to human MRPL46 (mitochondrial ribosomal protein L46). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpL46 in Genome Data Viewer
    Location:
    62B4-62B4; 3-1.0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1777439..1778347)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1777439..1778347)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase delta subunit 2 Neighboring gene uncharacterized protein Neighboring gene alpha Spectrin Neighboring gene antisense RNA:CR45834 Neighboring gene discs lost

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Appocher C, et al. Hum Mol Genet, 2014 Dec 20. PMID 25096240
    2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
    3. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article
    4. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, et al. Nat Commun, 2021 Dec 1. PMID 34853303, Free PMC Article
    5. Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. Sebastian B, et al. J Circadian Rhythms, 2022. PMID 36561348, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein L46
    Names
    CG13922-PA
    mRpL46-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1777439..1778347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139404.3 → NP_647661.1  mitochondrial ribosomal protein L46 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W086
      Related
      FBpp0072659
      Conserved Domains (2) summary
      cd04661
      Location:127 → 256
      MRP_L46; Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. ...
      pfam11788
      Location:26 → 133
      MRP-L46; 39S mitochondrial ribosomal protein L46
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W086 Q9W086

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