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    Tsp66A Tetraspanin 66A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp66Aprovided by FlyBase
    Official Full Name
    Tetraspanin 66Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035786
    Locus tag
    Dmel_CG16991
    See related
    AllianceGenome:FB:FBgn0035786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16991; Dm.Tsp66A; Dmel\CG16991
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp66A in Genome Data Viewer
    Location:
    66A2-66A2; 3-21 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7465509..7468808)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7458609..7461908)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
    2. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
    3. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article
    4. Minos as a genetic and genomic tool in Drosophila melanogaster. Metaxakis A, et al. Genetics, 2005 Oct. PMID 15972463, Free PMC Article
    5. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Xu C, et al. Cell Rep, 2019 Jan 15. PMID 30650359, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 66A
    Names
    CG16991-PC
    CG16991-PD
    CG16991-PE
    CG16991-PF
    Tsp66A-PC
    Tsp66A-PD
    Tsp66A-PE
    Tsp66A-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7465509..7468808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202134.1 → NP_001189063.1  tetraspanin 66A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ78
      Conserved Domains (2) summary
      cd03127
      Location:95 → 181
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:25 → 212
      Tetraspannin; Tetraspanin family

    2. NM_001274589.2 → NP_001261518.1  tetraspanin 66A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEE6
      Conserved Domains (2) summary
      cd03127
      Location:97 → 183
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:25 → 214
      Tetraspannin; Tetraspanin family

    3. NM_168216.4 → NP_729259.2  tetraspanin 66A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729259.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ78
      Conserved Domains (2) summary
      cd03127
      Location:95 → 181
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:25 → 212
      Tetraspannin; Tetraspanin family

    4. NM_001274590.2 → NP_001261519.1  tetraspanin 66A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEV5
      Conserved Domains (2) summary
      cd03127
      Location:95 → 179
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:25 → 210
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEE6 M9PEE6
    M9PEV5 M9PEV5
    Q8IQ78 Q8IQ78
    Q8MZG8 Q8MZG8

    Gene LinkOut

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