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    Jon66Ci Jonah 66Ci [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon66Ciprovided by FlyBase
    Official Full Name
    Jonah 66Ciprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035886
    Locus tag
    Dmel_CG7118
    See related
    AllianceGenome:FB:FBgn0035886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    66C; CG7118; Dmel\CG7118; Jon66C; Jon66ci; SP171
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon66Ci in Genome Data Viewer
    Location:
    66C10-66C10; 3-24 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8391540..8392377)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8384640..8385477)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Isocitrate dehydrogenase Neighboring gene Ecdysone-inducible gene E1 Neighboring gene Jonah 66Cii Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Participation of the Serine Protease Jonah66Ci in the Drosophila Antinematode Immune Response. Yadav S, et al. Infect Immun, 2019 Sep. PMID 31182620, Free PMC Article
    2. Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Erkosar B, et al. Cell Host Microbe, 2015 Oct 14. PMID 26439865, Free PMC Article
    3. Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model. Tan FHP, et al. Mol Neurobiol, 2023 Aug. PMID 37145377
    4. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
    5. D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition. Matos RC, et al. Nat Microbiol, 2017 Dec. PMID 28993620, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 66Ci
    Names
    CG7118-PA
    Jon66Ci-PA
    Jonah66Ci
    jonah 66C
    NP_729372.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8391540..8392377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168271.2 → NP_729372.1  jonah 66Ci [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSJ1
      Related
      FBpp0076335
      Conserved Domains (2) summary
      smart00020
      Location:36 → 251
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:37 → 254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSJ1 Q9VSJ1

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