ringer ringmaker [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ringerprovided by FlyBase
Official Full Name: ringmakerprovided by FlyBase
Primary source: FLYBASE:FBgn0266417
Locus tag: Dmel_CG45057
See related: AllianceGenome:FB:FBgn0266417
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG34249; CG45027; CG45057; CG4893; Dmel\CG45057; HDC10482; mdcds_27436; TPPP
Old locus tag: Dmel_CG34249; Dmel_CG4893
Summary: Predicted to enable tubulin binding activity. Involved in microtubule cytoskeleton organization; positive regulation of axon regeneration; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuromuscular junction; and neuronal cell body. Is expressed in several structures, including adult head; adult heart; gut section; larval CNS neuron; and midline glial cell. Used to study Parkinson's disease. Orthologous to several human genes including TPPP (tubulin polymerization promoting protein) and TPPP3 (tubulin polymerization promoting protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16354746..16359428, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16347846..16354990, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

Names: CG45057-PA; CG45057-PB; CG45057-PC; CG45057-PD; long-type TPPP; ringer-PA; ringer-PB; ringer-PC; ringer-PD; tubulin polymerization promoting protein