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    CG14182 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14182provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036922
    Locus tag
    Dmel_CG14182
    See related
    AllianceGenome:FB:FBgn0036922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14182
    Summary
    Predicted to be involved in negative regulation of smoothened signaling pathway. Predicted to be active in Golgi apparatus and ciliary membrane. Used to study chromosome 16p12.1 deletion syndrome. Orthologous to human MOSMO (modulator of smoothened). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14182 in Genome Data Viewer
    Location:
    76D7-76D7; 3-46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19978713..19979812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19971813..19972912, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenylyl cyclase 76E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hale-bopp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. Pizzo L, et al. PLoS Genet, 2021 Apr. PMID 33819264, Free PMC Article
    2. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
    3. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14182-PA
    CG14182-PB
    CG14182-PC
    CG14182-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19978713..19979812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300194.1 → NP_001287123.1  uncharacterized protein Dmel_CG14182, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW61
      Conserved Domains (1) summary
      pfam18800
      Location:25 → 166
      Atthog; Attenuator of Hedgehog

    2. NM_001275154.2 → NP_001262083.1  uncharacterized protein Dmel_CG14182, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIA7

    3. NM_140906.2 → NP_649163.1  uncharacterized protein Dmel_CG14182, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW61
      Related
      FBpp0074682
      Conserved Domains (1) summary
      pfam18800
      Location:25 → 166
      Atthog; Attenuator of Hedgehog

    4. NM_001275153.1 → NP_001262082.1  uncharacterized protein Dmel_CG14182, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW61
      Conserved Domains (1) summary
      pfam18800
      Location:25 → 166
      Atthog; Attenuator of Hedgehog
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PIA7 M9PIA7
    Q9VW61 Q9VW61

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