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    Dpck Dephospho-CoA kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dpckprovided by FlyBase
    Official Full Name
    Dephospho-CoA kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037469
    Locus tag
    Dmel_CG1939
    See related
    AllianceGenome:FB:FBgn0037469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1939; dDPCK; Dmel\CG1939; DPCK
    Summary
    Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in endomembrane system. Is expressed in adult head and organism. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dpck in Genome Data Viewer
    Location:
    84B2-84B2; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7082182..7083251)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2907904..2908973)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45908 Neighboring gene uncharacterized protein Neighboring gene RNA and export factor binding protein 1 Neighboring gene tailor Neighboring gene antisense RNA:CR45907 Neighboring gene alpha-Tubulin at 84B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Bosveld F, et al. Hum Mol Genet, 2008 Jul 1. PMID 18407920
    2. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    3. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    4. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
    5. Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. Ostalé CM, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599799, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in extrinsic component of mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Dephospho-CoA kinase
    Names
    CG1939-PA
    Dpck-PA
    NP_649692.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7082182..7083251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141435.3 → NP_649692.2  Dephospho-CoA kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649692.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SWY7, Q9VI57
      Related
      FBpp0081152
      Conserved Domains (1) summary
      cd02022
      Location:3 → 184
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWY7 Q8SWY7
    Q9VI57 Q9VI57

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