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    Spn85F Serpin 85F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn85Fprovided by FlyBase
    Official Full Name
    Serpin 85Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037772
    Locus tag
    Dmel_CG12807
    See related
    AllianceGenome:FB:FBgn0037772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12807; Dmel\CG12807
    Summary
    Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); HMSD (histocompatibility minor serpin domain containing); and SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn85F in Genome Data Viewer
    Location:
    85F5-85F5; 3-49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9997163..10000314)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5822885..5826036)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a Neighboring gene uncharacterized protein Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila MICAL regulates myofilament organization and synaptic structure. Beuchle D, et al. Mech Dev, 2007 May. PMID 17350233
    2. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    3. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    4. Identification of miR-305, a microRNA that promotes aging, and its target mRNAs in Drosophila. Ueda M, et al. Genes Cells, 2018 Feb. PMID 29314553
    5. Adult and Larval Tracheal Systems Exhibit Different Molecular Architectures in Drosophila. Bossen J, et al. Int J Mol Sci, 2023 Mar 15. PMID 36982710, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 85F
    Names
    CG12807-PA
    Spn85F-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9997163..10000314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141708.3 → NP_649965.2  serpin 85F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649965.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH46
      Conserved Domains (1) summary
      cl00137
      Location:450 → 634
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH46 Q9VH46

    Gene LinkOut

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