wkd whacked [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wkdprovided by FlyBase
Official Full Name: whackedprovided by FlyBase
Primary source: FLYBASE:FBgn0037917
Locus tag: Dmel_CG5344
See related: AllianceGenome:FB:FBgn0037917
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg5344; CG5344; Dmel\CG5344; Wkd
Summary: Predicted to enable GTPase activator activity. Involved in lumen formation, open tracheal system and polarity specification of proximal/distal axis. Located in cytoplasm; cytoplasmic side of apical plasma membrane; and filopodium. Is expressed in embryonic head epidermis; embryonic hindgut; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to several human genes including TBC1D10A (TBC1 domain family member 10A) and TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11581576..11585305)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7407298..7411027)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lumen formation, open tracheal system	HMP more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of proximal/distal axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain