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    Sur-8 Sur-8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sur-8provided by FlyBase
    Official Full Name
    Sur-8provided by FlyBase
    Primary source
    FLYBASE:FBgn0038504
    Locus tag
    Dmel_CG5407
    See related
    AllianceGenome:FB:FBgn0038504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5407; CT17146; Dmel\CG5407; SUR-8; Sur8
    Summary
    Predicted to enable volume-sensitive anion channel activity. Involved in positive regulation of Ras protein signal transduction. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sur-8 in Genome Data Viewer
    Location:
    90A5-90A5; 3-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17395199..17402515, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13220921..13228237, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44160 Neighboring gene sds22 Neighboring gene Cellular Repressor of E1A-stimulated Genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Critical contribution of linker proteins to Raf kinase activation. Anselmo AN, et al. J Biol Chem, 2002 Feb 22. PMID 11741918
    2. SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila. Xue Y, et al. PLoS Genet, 2019 Nov. PMID 31710605, Free PMC Article
    3. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
    4. How Genetics Has Helped Piece Together the MAPK Signaling Pathway. Ashton-Beaucage D, et al. Methods Mol Biol, 2017. PMID 27924555
    5. Analysis of the eye developmental pathway in Drosophila using DNA microarrays. Michaut L, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12655063, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables volume-sensitive anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction HGI PubMed 

    General protein information

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    Preferred Names
    Sur-8
    Names
    CG5407-PA
    CG5407-PB
    CG5407-PE
    CG5407-PF
    Sur-8-PA
    Sur-8-PB
    Sur-8-PE
    Sur-8-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17395199..17402515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169758.4 → NP_732231.2  Sur-8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732231.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB5, Q8MQM0, Q9VEK6
      UniProtKB/TrEMBL
      A0A0B4KHN4
      Conserved Domains (3) summary
      cd00116
      Location:204 → 401
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:207 → 264
      LRR_8; Leucine rich repeat

    2. NM_001275736.1 → NP_001262665.1  Sur-8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA2
      Conserved Domains (3) summary
      cd00116
      Location:204 → 401
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:207 → 264
      LRR_8; Leucine rich repeat

    3. NM_142363.7 → NP_650620.3  Sur-8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650620.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB5, Q8MQM0, Q9VEK6
      UniProtKB/TrEMBL
      A0A0B4KHN4
      Conserved Domains (3) summary
      cd00116
      Location:204 → 401
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:207 → 264
      LRR_8; Leucine rich repeat

    4. NM_001275735.1 → NP_001262664.1  Sur-8, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB5, Q8MQM0, Q9VEK6
      UniProtKB/TrEMBL
      A0A0B4KHN4
      Conserved Domains (3) summary
      cd00116
      Location:204 → 401
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:207 → 264
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHA2 A0A0B4KHA2
    A0A0B4KHN4 A0A0B4KHN4
    Q9VEK6.3 Q9VEK6

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