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    SLC7A1 solute carrier family 7 member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 539465, updated on 29-Jan-2025

    Summary

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    Official Symbol
    SLC7A1provided by VGNC
    Official Full Name
    solute carrier family 7 member 1provided by VGNC
    Primary source
    VGNC:VGNC:34924
    See related
    Ensembl:ENSBTAG00000018577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CAT1; CAT-1
    Orthologs
    human mouse all
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    Genomic context

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    See SLC7A1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (30934146..30996703)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346760 Neighboring gene uncharacterized LOC107132982 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene microtubule associated scaffold protein 2 Neighboring gene uncharacterized LOC132346761 Neighboring gene solute carrier family 46 member 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Overexpression of bovine leukemia virus receptor SLC7A1/CAT1 enhances cellular susceptibility to BLV infection on luminescence syncytium induction assay (LuSIA). Sato H, et al. Virol J, 2020 Apr 22. PMID 32321527, Free PMC Article
    2. Identification and expression pattern of cationic amino acid transporter-1 mRNA in small intestinal epithelia of Angus steers at four production stages. Liao SF, et al. J Anim Sci, 2008 Mar. PMID 17998425
    3. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells. Chicoine LG, et al. Am J Physiol Lung Cell Mol Physiol, 2011 Apr. PMID 21239536, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of bovine leukemia virus receptor SLC7A1/CAT1 enhances cellular susceptibility to BLV infection on luminescence syncytium induction assay (LuSIA).
      Title: Overexpression of bovine leukemia virus receptor SLC7A1/CAT1 enhances cellular susceptibility to BLV infection on luminescence syncytium induction assay (LuSIA).
    2. Lipopolysaccharide/tumor necrosis factor-alpha treatment increased the expression of iNOS, arginase II, CAT-1, and CAT-2 mRNA.
      Title: Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables L-lysine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables L-ornithine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-arginine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in L-ornithine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cationic amino acid transporter 1
    Names
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
    system Y+ basic amino acid transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135792.1 → NP_001129264.1  high affinity cationic amino acid transporter 1

      See identical proteins and their annotated locations for NP_001129264.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000012
      UniProtKB/TrEMBL
      F1N5P6
      Conserved Domains (1) summary
      TIGR00906
      Location:9 → 610
      2A0303; cationic amino acid transport permease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      30934146..30996703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999940.2 → XP_024855708.1  high affinity cationic amino acid transporter 1 isoform X1

      Conserved Domains (1) summary
      TIGR00906
      Location:9 → 615
      2A0303; cationic amino acid transport permease

    2. XM_024999942.2 → XP_024855710.1  high affinity cationic amino acid transporter 1 isoform X2

      UniProtKB/TrEMBL
      F1N5P6
      Related
      ENSBTAP00070010296.1, ENSBTAT00070017693.1
      Conserved Domains (1) summary
      TIGR00906
      Location:9 → 610
      2A0303; cationic amino acid transport permease

    3. XM_024999941.2 → XP_024855709.1  high affinity cationic amino acid transporter 1 isoform X1

      Conserved Domains (1) summary
      TIGR00906
      Location:9 → 615
      2A0303; cationic amino acid transport permease

    4. XM_024999943.2 → XP_024855711.1  high affinity cationic amino acid transporter 1 isoform X2

      UniProtKB/TrEMBL
      F1N5P6
      Conserved Domains (1) summary
      TIGR00906
      Location:9 → 610
      2A0303; cationic amino acid transport permease

    5. XM_059892099.1 → XP_059748082.1  high affinity cationic amino acid transporter 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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