U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CFH complement factor H [ Bos taurus (domestic cattle) ]

    Gene ID: 280816, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Gene symbol
    CFH
    Gene description
    complement factor H
    See related
    Ensembl:ENSBTAG00000023177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HF1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CFH in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (6199768..6333365, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC790886 Neighboring gene complement factor H-like Neighboring gene potassium sodium-activated channel subfamily T member 2 Neighboring gene uncharacterized LOC101907330

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b. Soames CJ, et al. Biochem J, 1996 Apr 15. PMID 8615824, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC129039

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables complement component C3b binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    complement factor H
    Names
    H factor 1 (complement)
    NP_001029108.1
    XP_024831741.1
    XP_024831742.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033936.1 → NP_001029108.1  complement factor H precursor

      See identical proteins and their annotated locations for NP_001029108.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105258
      UniProtKB/Swiss-Prot
      Q28085, Q3MHF3, Q9TQZ7
      UniProtKB/TrEMBL
      A0A3Q1LS74
      Related
      ENSBTAP00000098208.1, ENSBTAT00000093037.1
      Conserved Domains (4) summary
      cd00033
      Location:146 → 206
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:870 → 934
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:11 → 263
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:85 → 141
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6199768..6333365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975973.2 → XP_024831741.1  complement factor H isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LS74, A0AAA9SHR4
      Related
      ENSBTAP00000082053.1, ENSBTAT00000089110.1
      Conserved Domains (1) summary
      cl27761
      Location:6 → 263
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    2. XM_024975974.2 → XP_024831742.1  complement factor H isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LS74
      Conserved Domains (2) summary
      cd00033
      Location:26 → 76
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl27761
      Location:632 → 853
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28085.3 GenPept UniProtKB/Swiss-Prot:Q28085

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials