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    CDH5 cadherin 5 [ Bos taurus (domestic cattle) ]

    Gene ID: 414735, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CDH5provided by VGNC
    Official Full Name
    cadherin 5provided by VGNC
    Primary source
    VGNC:VGNC:97252
    See related
    Ensembl:ENSBTAG00000007421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See CDH5 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (34122721..34159010)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene uncharacterized LOC104974812 Neighboring gene brain expressed associated with NEDD4 1 Neighboring gene thymidine kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells. Ohashi T, et al. J Biomech, 2007. PMID 17261311
    2. VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function. Iyer S, et al. Am J Physiol Lung Cell Mol Physiol, 2004 Jun. PMID 14672921
    3. VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. Nelson CM, et al. J Cell Sci, 2003 Sep 1. PMID 12876221
    4. Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Gray DS, et al. Exp Cell Res, 2008 Sep 10. PMID 18652824, Free PMC Article
    5. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Wang Y, et al. Proc Natl Acad Sci U S A, 2006 Feb 7. PMID 16446427, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VE-cadherin induces opposing growth signals.
      Title: VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension.
    2. In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.
      Title: Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.
    3. exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure
      Title: Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells.
    4. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
      Title: Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.
    5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
      Title: Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
    6. investigated the role of catenin p120-VE-cadherin interaction in regulation of barrier function in confluent endothelial monolayers
      Title: VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.
    7. a VE-cadherin-dependent pathway may link T2-TrpRS to inhibition of new blood vessel formation
      Title: VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-5
    Names
    VE-cadherin
    cadherin 5, type 2 (vascular endothelium)
    cadherin 5, type 2, VE-cadherin (vascular endothelium)
    cadherin 5, type 2, VE-cadherin (vascular epithelium)
    vascular endothelial cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001601.1 → NP_001001601.1  cadherin-5 precursor

      See identical proteins and their annotated locations for NP_001001601.1

      Status: PROVISIONAL

      Source sequence(s)
      AY363224
      UniProtKB/Swiss-Prot
      Q6URK6
      UniProtKB/TrEMBL
      G3MZL1, G5E588
      Related
      ENSBTAP00000009760.6, ENSBTAT00000009760.7
      Conserved Domains (3) summary
      cd11304
      Location:261 → 367
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 147
      CA; Cadherin repeats
      pfam01049
      Location:633 → 774
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34122721..34159010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6URK6.1 GenPept UniProtKB/Swiss-Prot:Q6URK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials