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    ARRB2 arrestin beta 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281638, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ARRB2provided by VGNC
    Official Full Name
    arrestin beta 2provided by VGNC
    Primary source
    VGNC:VGNC:26170
    See related
    Ensembl:ENSBTAG00000035587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARRB2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (26634445..26643103, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene mediator complex subunit 11 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene uncharacterized LOC112442630 Neighboring gene microRNA mir-2338 Neighboring gene arachidonate 15-lipoxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein-coupled receptors. Jean-Charles PY, et al. J Biol Chem, 2022 May. PMID 35307348, Free PMC Article
    2. Quantitative morphological analysis of arrestin2 clustering upon G protein-coupled receptor stimulation by super-resolution microscopy. Truan Z, et al. J Struct Biol, 2013 Nov. PMID 24091038
    3. Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. Kern RC, et al. Biochemistry, 2009 Aug 4. PMID 19555118, Free PMC Article
    4. Structural basis of arrestin-3 activation and signaling. Chen Q, et al. Nat Commun, 2017 Nov 10. PMID 29127291, Free PMC Article
    5. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. Gaidarov I, et al. EMBO J, 1999 Feb 15. PMID 10022830, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A single phenylalanine residue in beta-arrestin2 critically regulates its binding to G protein-coupled receptors.
      Title: A single phenylalanine residue in β-arrestin2 critically regulates its binding to G protein-coupled receptors.
    2. The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.
      Title: Quantitative morphological analysis of arrestin2 clustering upon G protein-coupled receptor stimulation by super-resolution microscopy.
    3. K2A mutations in arrestin-1, -2, and -3 significantly reduced their binding to active phosphorhodopsin.
      Title: Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.
    4. Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
      Title: Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables angiotensin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-arrestin-2
    Names
    arrestin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205277.2 → NP_001192206.1  beta-arrestin-2

      See identical proteins and their annotated locations for NP_001192206.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000019
      UniProtKB/Swiss-Prot
      O77565, O77566, P32120
      Related
      ENSBTAP00070020157.1, ENSBTAT00070033995.1
      Conserved Domains (2) summary
      smart01017
      Location:194 → 349
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26634445..26643103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005220181.5 → XP_005220238.1  beta-arrestin-2 isoform X1

      UniProtKB/Swiss-Prot
      O77565, O77566, P32120
      Related
      ENSBTAP00070020164.1, ENSBTAT00070034004.1
      Conserved Domains (2) summary
      smart01017
      Location:194 → 349
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32120.1 GenPept UniProtKB/Swiss-Prot:P32120

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.