DUSP1 dual specificity phosphatase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DUSP1provided by VGNC
Official Full Name: dual specificity phosphatase 1provided by VGNC
Primary source: VGNC:VGNC:28248
See related: BGD:BT17682; Ensembl:ENSBTAG00000013863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MKP-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (4540528..4543611, complement)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abundance of Dual Specificity Phosphatase (DUSP) 1 and DUSP6 mRNA Is Regulated by Hippo Signaling in Bovine Pre-ovulatory Granulosa Cells.
Title: Abundance of Dual Specificity Phosphatase (DUSP) 1 and DUSP6 mRNA Is Regulated by Hippo Signaling in Bovine Pre-ovulatory Granulosa Cells.
DUSP1 regulates cell cycle progression and apoptosis in cumulus cells by affecting mitochondrial function, oxidative stress, and autophagy.
Title: Dual-specificity phosphatase 1 regulates cell cycle progression and apoptosis in cumulus cells by affecting mitochondrial function, oxidative stress, and autophagy.
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.
Title: Angiotensin II-induced mitogen-activated protein kinase phosphatase-1 expression in bovine adrenal glomerulosa cells: implications in mineralocorticoid biosynthesis.

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General gene information

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Markers

MARC_2571-2572:991932827:3 (e-PCR)
- UniSTS:230923

DUSP1 (e-PCR)
- UniSTS:504847

DUSP4 (e-PCR)
- UniSTS:519308

MARC1787-1788 (e-PCR)
- UniSTS:207075

MARC_1787-1788:991931334:3 (e-PCR)
- UniSTS:207075

MARC_1787-1788:996678930:1 (e-PCR)
- UniSTS:207075

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in endoderm formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 1

Names: MAP kinase phosphatase-1

NP_001039917.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001046452.2 → NP_001039917.1 dual specificity protein phosphatase 1

See identical proteins and their annotated locations for NP_001039917.1

Status: PROVISIONAL

Source sequence(s)

BC105384

UniProtKB/TrEMBL

Q2KJE3

Related

ENSBTAP00000018411.2, ENSBTAT00000018411.4

Conserved Domains (3) summary

COG2453
Location:188 → 313

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

cd00127
Location:173 → 309

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:7 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...