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    MAPK1 mitogen-activated protein kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 327672, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MAPK1provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:31212
    See related
    EnsemblRapid:ENSBTAG00070019110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ERK2
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See MAPK1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (71998246..72050979)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase III beta Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene U6 spliceosomal RNA Neighboring gene large ribosomal subunit protein eL39-like Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase like 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis. Lu LM, et al. Molecules, 2012 Dec 27. PMID 23271465, Free PMC Article
    2. ERK1/2-dependent gene expression in the bovine ovulating follicle. Schuermann Y, et al. Sci Rep, 2018 Nov 1. PMID 30385793, Free PMC Article
    3. The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level. Gao Y, et al. Cell Physiol Biochem, 2014. PMID 25500918
    4. Cyclic mechanical stress suppresses myogenic differentiation of adult bovine satellite cells through activation of extracellular signal-regulated kinase. Kook SH, et al. Mol Cell Biochem, 2008 Feb. PMID 18008139
    5. Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms. Liu D, et al. Endocrinology, 2008 Mar. PMID 18079198, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways.
      Title: Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways.
    2. both granulosa and theca cells of ERK1/2-inhibited follicles had higher expression of SLC16A1, a monocarboxylate transporter, transporting substances including beta-hydroxybutyrate across the plasma membrane. Taken together, ERK1/2 plays a significant role in mediating LH surge-induced gene expression in granulosa and theca cells of the ovulating follicle in cattle.
      Title: ERK1/2-dependent gene expression in the bovine ovulating follicle.
    3. The present results suggest that demecolcine might contribute to the activation of the Mos/MAPK pathway and affect spindle structure
      Title: The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level.
    4. MAPK1 upregulated milk protein synthesis through the Stat5 and mTOR pathways.
      Title: Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis.
    5. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
      Title: Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
    6. ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
      Title: Endoplasmic reticulum Ca2+ release modulates endothelial nitric-oxide synthase via extracellular signal-regulated kinase (ERK) 1/2-mediated serine 635 phosphorylation.
    7. Cyclin-dependent kinase inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF) and MAPK, and had nearly no effect on kinase activities during maturation.
      Title: Effect of cyclin-dependent kinase (CDK) inhibition on expression, localization and activity of maturation promoting factor (MPF) and mitogen activated protein kinase (MAPK) in bovine oocytes.
    8. Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
      Title: Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
    9. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
      Title: Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
    10. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
      Title: Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 1
    Names
    ERK-2
    ERT1
    MAP kinase 1
    MAP kinase 2
    MAPK 1
    MAPK 2
    extracellular signal-regulated kinase 2
    mitogen-activated protein kinase 2
    p42-MAPK
    NP_786987.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175793.2 → NP_786987.1  mitogen-activated protein kinase 1

      See identical proteins and their annotated locations for NP_786987.1

      Status: PROVISIONAL

      Source sequence(s)
      Z14089
      UniProtKB/Swiss-Prot
      A2VE60, P46196
      UniProtKB/TrEMBL
      A0AAF6YUK9
      Related
      ENSBTAP00070025864.1, ENSBTAT00070043140.1
      Conserved Domains (1) summary
      cd07849
      Location:19 → 353
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      71998246..72050979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46196.3 GenPept UniProtKB/Swiss-Prot:P46196

    Gene LinkOut

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