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    PLD1 phospholipase D1 [ Bos taurus (domestic cattle) ]

    Gene ID: 514554, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PLD1provided by VGNC
    Official Full Name
    phospholipase D1provided by VGNC
    Primary source
    VGNC:VGNC:50244
    See related
    BGD:BT12890; Ensembl:ENSBTAG00000017490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PLD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (95687380..95963604)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345697 Neighboring gene uncharacterized LOC132345694 Neighboring gene uncharacterized LOC132345699 Neighboring gene transmembrane protein 212 Neighboring gene small ribosomal subunit protein eS6-like Neighboring gene Krueppel-like factor 3 pseudogene Neighboring gene uncharacterized LOC132345702 Neighboring gene uncharacterized LOC101905533 Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene thymosin beta-4-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells. Qin H, et al. J Endocrinol, 2009 Jul. PMID 19372190, Free PMC Article
    2. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. Olala LO, et al. Mol Cell Endocrinol, 2013 Feb 5. PMID 23178798, Free PMC Article
    3. Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions. Nishihara H, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16785431, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
      Title: A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
    2. Ca(2+) entry only through certain Ca(2+) influx pathways is linked to PLD activation.
      Title: The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC166213

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of microvillus assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholipase D1
    Names
    phospholipase D1, phosphatidylcholine-specific
    NP_001095471.1
    XP_005201734.1
    XP_005201735.1
    XP_005201736.1
    XP_005201738.1
    XP_005201739.1
    XP_010799678.1
    XP_015327978.1
    XP_024841831.1
    XP_059738089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102001.1 → NP_001095471.1  phospholipase D1

      See identical proteins and their annotated locations for NP_001095471.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150123
      UniProtKB/TrEMBL
      A0AAF6DLJ7, A6QR57, F1MZI9
      Related
      ENSBTAP00000042452.4, ENSBTAT00000045023.5
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09844
      Location:714 → 895
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1019
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:353 → 501
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95687380..95963604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015472492.3 → XP_015327978.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LL74, A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754 → 935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    2. XM_005201681.5 → XP_005201738.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_005201738.1

      UniProtKB/TrEMBL
      A0A3Q1LL74, A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754 → 935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    3. XM_005201682.5 → XP_005201739.1  phospholipase D1 isoform X3

      See identical proteins and their annotated locations for XP_005201739.1

      UniProtKB/TrEMBL
      A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716 → 897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1021
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    4. XM_059882106.1 → XP_059738089.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LL74, A0AAF6DLJ7

    5. XM_024986063.2 → XP_024841831.1  phospholipase D1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LM46
      Related
      ENSBTAP00000069972.2, ENSBTAT00000068010.2
      Conserved Domains (1) summary
      cl26365
      Location:82 → 1002
      PLN03008; Phospholipase D delta

    6. XM_005201677.5 → XP_005201734.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_005201734.1

      UniProtKB/TrEMBL
      A0A3Q1LL74, A0AAF6DLJ7
      Related
      ENSBTAP00000060513.2, ENSBTAT00000076794.2
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754 → 935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    7. XM_005201679.5 → XP_005201736.1  phospholipase D1 isoform X3

      See identical proteins and their annotated locations for XP_005201736.1

      UniProtKB/TrEMBL
      A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716 → 897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1021
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    8. XM_010801376.4 → XP_010799678.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_010799678.1

      UniProtKB/TrEMBL
      A0A3Q1LL74, A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:78 → 210
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:353 → 503
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754 → 935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:82 → 1059
      PLN02866; phospholipase D
      cd01254
      Location:198 → 327
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    9. XM_005201678.3 → XP_005201735.1  phospholipase D1 isoform X2

      UniProtKB/TrEMBL
      A0AAF6DLJ7
      Conserved Domains (5) summary
      cd07296
      Location:42 → 174
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:317 → 467
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:718 → 899
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:46 → 1023
      PLN02866; phospholipase D
      cd01254
      Location:162 → 291
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    RNA

    1. XR_009493069.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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