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    ACTN1 actinin alpha 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 524770, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ACTN1provided by VGNC
    Official Full Name
    actinin alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:25581
    See related
    BGD:BT12442; Ensembl:ENSBTAG00000018255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ACTN1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (80672876..80770960, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ZFP36 ring finger protein like 1 Neighboring gene GTP-binding nuclear protein Ran-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132346405 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation and properties of brain alpha-actinin. Schook W, et al. Biochem J, 1978 Oct 1. PMID 153745, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128689

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin-1
    Names
    F-actin cross-linking protein
    non-muscle alpha-actinin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035351.2 → NP_001030428.1  alpha-actinin-1

      See identical proteins and their annotated locations for NP_001030428.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107533
      UniProtKB/Swiss-Prot
      Q3B7N2
      UniProtKB/TrEMBL
      A4ZZF8
      Related
      ENSBTAP00070045879.1, ENSBTAT00070075212.1
      Conserved Domains (6) summary
      cd00051
      Location:750 → 817
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:822 → 888
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      80672876..80770960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211979.3 → XP_005212036.1  alpha-actinin-1 isoform X2

      See identical proteins and their annotated locations for XP_005212036.1

      UniProtKB/TrEMBL
      A0A3Q1MBS5
      Related
      ENSBTAP00070045943.1, ENSBTAT00070075305.1
      Conserved Domains (5) summary
      COG5069
      Location:29 → 292
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:274 → 384
      Spectrin; Spectrin repeat
      pfam08726
      Location:816 → 882
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:743 → 846
      EFh_PEF; The penta-EF hand (PEF) family

    2. XM_005211978.4 → XP_005212035.1  alpha-actinin-1 isoform X1

      See identical proteins and their annotated locations for XP_005212035.1

      UniProtKB/TrEMBL
      A0A3Q1MBS5
      Related
      ENSBTAP00070045661.1, ENSBTAT00070074944.1
      Conserved Domains (6) summary
      COG5126
      Location:743 → 847
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:817 → 883
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    3. XM_005211976.3 → XP_005212033.1  alpha-actinin-1 isoform X4

      See identical proteins and their annotated locations for XP_005212033.1

      UniProtKB/TrEMBL
      A0A3Q1MPS4, A4ZZF8
      Related
      ENSBTAP00070045834.1, ENSBTAT00070075160.1
      Conserved Domains (6) summary
      cd00051
      Location:750 → 839
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:395 → 622
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:634 → 733
      Spectrin; Spectrin repeat
      pfam08726
      Location:844 → 910
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:28 → 132
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:136 → 250
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    4. XM_059890434.1 → XP_059746417.1  alpha-actinin-1 isoform X3

      UniProtKB/TrEMBL
      A4ZZF8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7N2.1 GenPept UniProtKB/Swiss-Prot:Q3B7N2

    Gene LinkOut

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