POU1F1 POU class 1 homeobox 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: POU1F1provided by VGNC
Official Full Name: POU class 1 homeobox 1provided by VGNC
Primary source: VGNC:VGNC:53599
See related: BGD:BT19875; Ensembl:ENSBTAG00000009128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: Pit1; GHF-1; Pit-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (35417574..35435629, complement)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of miR-23b-3p on regulating GH by targeting POU1F1 in Yanbian yellow cattle.
Title: The effect of miR-23b-3p on regulating GH by targeting POU1F1 in Yanbian yellow cattle.
The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.
Title: Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle.
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 gene (AB) was desirable
Title: Effect of polymorphic variants of GH, Pit-1, and beta-LG genes on milk production of Holstein cows.
results showed that GC genotype at 1178 locus of POU1F1 gene was advantageous for milk yield, milk protein yield, and milk fat yield
Title: [Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Holstein cattle].
expression analysis of pathway genes in preimplantation embryos
Title: Short communication: expression and alternative splicing of POU1F1 pathway genes in preimplantation bovine embryos.
Study of genetic variation in Yakutian cattle (Bos taurus L.) using the prolactin bPRL, growth hormone bGH, and transcription factor bPit-1 genes
Title: [Study of genetic variation in Yakutian cattle (Bos taurus L.) using the prolactin bPRL, growth hormone bGH, and transcription factor bPit-1 genes].
The association of the polymorphism of the POU1F1 gene with growth traits among Qinchuan, Limousin x Qinchuan, Angus x Qinchuan and Germany Yellow x Qinchuan crosses was analyzed.
Title: Associations of a HinfI PCR-RFLP of POU1F1 gene with growth traits in Qinchuan cattle.
Results estimate the allele frequencies in polymorphic site of exon six of POU1F1 in three Iranian native and Holstein cattle, and show no significant association between POU1F1 polymorphism and milk production.
Title: Polymorphism of the bovine POU1F1 gene: allele frequencies and effects on milk production in three Iranian native breeds and Holstein cattle of Iran.
The POU1F1 gene is associated with economically important traits in dairy cattle; an SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified.
Title: A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle.
No significant associations of the TaqI polymorphism of the bovine POU1F1 gene with body weight and average daily gain for different growth periods were observed.
Title: A TaqI PCR-RFLP detecting a novel SNP in exon 2 of the bovine POU1F1 gene.

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General gene information

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Markers

POU1F1 (e-PCR)
- UniSTS:506146

POU1F1 (e-PCR)
- UniSTS:278932

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pituitary-specific positive transcription factor 1

Names: POU domain, class 1, transcription factor 1; growth hormone factor 1; growth hormone factor I; pituitary growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174579.4 → NP_777004.2 pituitary-specific positive transcription factor 1

Status: VALIDATED

Source sequence(s)

DAAA02000842

UniProtKB/Swiss-Prot

P10036

UniProtKB/TrEMBL

F1MR82

Related

ENSBTAP00070006423.1, ENSBTAT00070011250.1

Conserved Domains (2) summary

smart00352
Location:124 → 198

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:217 → 271

Homeobox; Homeobox domain