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    ACTN4 actinin alpha 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 522269, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ACTN4provided by VGNC
    Official Full Name
    actinin alpha 4provided by VGNC
    Primary source
    VGNC:VGNC:25583
    See related
    BGD:BT10227; Ensembl:ENSBTAG00000011215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ACTN4 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (48402809..48476686)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene calpain 12 Neighboring gene transfer RNA glutamic acid (anticodon CUC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin-4
    Names
    F-actin cross-linking protein
    non-muscle alpha-actinin 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098052.1 → NP_001091521.1  alpha-actinin-4

      See identical proteins and their annotated locations for NP_001091521.1

      Status: PROVISIONAL

      Source sequence(s)
      BC140512
      UniProtKB/Swiss-Prot
      A5D7D1
      UniProtKB/TrEMBL
      A0A452DIE5
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:841 → 907
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:759 → 868
      EFh_PEF; The penta-EF hand (PEF) family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48402809..48476686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024978283.2 → XP_024834051.1  alpha-actinin-4 isoform X7

      UniProtKB/TrEMBL
      A0A452DIE5, A0AAA9RTZ4
      Related
      ENSBTAP00070024199.1, ENSBTAT00070040716.1
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:863 → 929
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:762 → 893
      EFh_PEF; The penta-EF hand (PEF) family

    2. XM_024978286.2 → XP_024834054.1  alpha-actinin-4 isoform X10

      UniProtKB/TrEMBL
      A0A452DIE5
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      COG5126
      Location:762 → 866
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:836 → 902
      EFhand_Ca_insen; Ca2+ insensitive EF hand

    3. XM_024978284.2 → XP_024834052.1  alpha-actinin-4 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1MAJ8, A0A452DIE5
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:863 → 929
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:762 → 893
      EFh_PEF; The penta-EF hand (PEF) family

    4. XM_024978285.2 → XP_024834053.1  alpha-actinin-4 isoform X9

      UniProtKB/TrEMBL
      A0A452DIE5
      Related
      ENSBTAP00070024163.1, ENSBTAT00070040671.1
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:841 → 907
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:759 → 868
      EFh_PEF; The penta-EF hand (PEF) family

    5. XM_024978288.2 → XP_024834056.1  alpha-actinin-4 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1MRU0, A0A452DIE5
      Related
      ENSBTAP00070024229.1, ENSBTAT00070040746.1
      Conserved Domains (5) summary
      COG5069
      Location:48 → 311
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      COG5126
      Location:762 → 866
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:293 → 403
      Spectrin; Spectrin repeat
      pfam08726
      Location:836 → 902
      EFhand_Ca_insen; Ca2+ insensitive EF hand

    6. XM_024978282.2 → XP_024834050.1  alpha-actinin-4 isoform X6

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      COG5126
      Location:849 → 953
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:923 → 989
      EFhand_Ca_insen; Ca2+ insensitive EF hand

    7. XM_024978278.2 → XP_024834046.1  alpha-actinin-4 isoform X2

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:950 → 1016
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:849 → 980
      EFh_PEF; The penta-EF hand (PEF) family

    8. XM_024978280.2 → XP_024834048.1  alpha-actinin-4 isoform X4

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:928 → 994
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:846 → 955
      EFh_PEF; The penta-EF hand (PEF) family

    9. XM_024978277.2 → XP_024834045.1  alpha-actinin-4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:950 → 1016
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:849 → 980
      EFh_PEF; The penta-EF hand (PEF) family

    10. XM_024978281.2 → XP_024834049.1  alpha-actinin-4 isoform X5

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      COG5126
      Location:849 → 953
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:923 → 989
      EFhand_Ca_insen; Ca2+ insensitive EF hand

    11. XM_024978279.2 → XP_024834047.1  alpha-actinin-4 isoform X3

      UniProtKB/TrEMBL
      A0AAA9RXM6
      Conserved Domains (5) summary
      COG5069
      Location:142 → 398
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:501 → 727
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:380 → 490
      Spectrin; Spectrin repeat
      pfam08726
      Location:928 → 994
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl25352
      Location:846 → 955
      EFh_PEF; The penta-EF hand (PEF) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5D7D1.1 GenPept UniProtKB/Swiss-Prot:A5D7D1

    Gene LinkOut

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