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    CG4815 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4815provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039568
    Locus tag
    Dmel_CG4815
    See related
    AllianceGenome:FB:FBgn0039568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4815; SP189
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in sexual reproduction. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4815 in Genome Data Viewer
    Location:
    98B7-98B7; 3-94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27989699..27990751, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23815421..23816473, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 97EF Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46087 Neighboring gene long noncoding RNA: testis-specific 27 Neighboring gene trivet

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes. LaFlamme BA, et al. PLoS Genet, 2012 Jan. PMID 22253601, Free PMC Article
    2. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. Castillo DM, et al. BMC Evol Biol, 2011 Sep 14. PMID 21917173, Free PMC Article
    3. Identification and function of proteolysis regulators in seminal fluid. Laflamme BA, et al. Mol Reprod Dev, 2013 Feb. PMID 23109270, Free PMC Article
    4. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    5. A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. Owings KG, et al. G3 (Bethesda), 2024 Feb 7. PMID 38098286, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4815-PA
    NP_651607.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27989699..27990751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143350.2 → NP_651607.1  uncharacterized protein Dmel_CG4815 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAX6
      Related
      FBpp0084629
      Conserved Domains (2) summary
      pfam00089
      Location:49 → 256
      Trypsin; Trypsin
      cl21584
      Location:49 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAX6 Q9VAX6

    Gene LinkOut

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