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    CARTPT CART prepropeptide [ Bos taurus (domestic cattle) ]

    Gene ID: 493726, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CARTPTprovided by VGNC
    Official Full Name
    CART prepropeptideprovided by VGNC
    Primary source
    VGNC:VGNC:26774
    See related
    Ensembl:ENSBTAG00000047486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CART
    Orthologs
    human mouse all
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    Genomic context

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    See CARTPT in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (9865310..9868125, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343207 Neighboring gene uncharacterized LOC132343209 Neighboring gene methylcrotonyl-CoA carboxylase subunit 2 Neighboring gene peptidyl-prolyl cis-trans isomerase FKBP2-like Neighboring gene large ribosomal subunit protein eL15-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Immunodetection of cocaine- and amphetamine-regulated transcript in bovine pancreas. Janiuk I, et al. Acta Histochem, 2015 Jul. PMID 25953739
    2. Regulation of granulosa cell cocaine and amphetamine regulated transcript (CART) binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle. Folger JK, et al. Biol Reprod, 2013 Dec. PMID 24174573
    3. Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle. Janiuk I, et al. Acta Histochem, 2013 May. PMID 23084786
    4. The polymorphisms of bovine cocaine- and amphetamine-regulated transcripts and their associations with cattle (Bos taurus) growth traits. Zhang CL, et al. J Biosci, 2008 Sep. PMID 19005236
    5. The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery. Valle E, et al. Anim Genet, 2005 Feb. PMID 15670137

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CART peptide in the normal pancreas has been identified in intrapancreatic ganglia, nerve fibres and in endocrine cells of Langerhans islets and exocrine pancreas.
      Title: Immunodetection of cocaine- and amphetamine-regulated transcript in bovine pancreas.
    2. these results demonstrate hormonal regulation of granulosa cell CART binding in vitro and temporal regulation of CART binding in subordinate follicles during dominant follicle selection. Results also suggest that CART signaling may help suppress estradiol-producing capacity of the F2 (subordinate) follicle during this time period.
      Title: Regulation of granulosa cell cocaine and amphetamine regulated transcript (CART) binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle.
    3. cocaine and amphetamine regulated transcript
      Title: Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle.
    4. A potential stage-specific regulatory role for CART in negative regulation of estradiol production associated with selection of the dominant follicle.
      Title: Evidence supporting a role for cocaine- and amphetamine-regulated transcript (CARTPT) in control of granulosa cell estradiol production associated with dominant follicle selection in cattle.
    5. The intracellular mechanism of action of CART in regulation of FSH-induced MAPK signaling.
      Title: Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein kinase phosphatases in bovine granulosa cells.
    6. Two single-nucleotide polymorphisms show an association between genotype and body weight.
      Title: The polymorphisms of bovine cocaine- and amphetamine-regulated transcripts and their associations with cattle (Bos taurus) growth traits.
    7. Potent inhibitory effects of CART on multiple components of the follitropin signaling pathway linked to follicular development.
      Title: Cocaine- and amphetamine-regulated transcript regulation of follicle-stimulating hormone signal transduction in bovine granulosa cells.
    8. DNA sequence of the complete coding region of the bovine CART gene
      Title: The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery.
    9. CART may be a novel local regulator of follicular atresia in the bovine ovary[CART]
      Title: Evidence that cocaine- and amphetamine-regulated transcript is a novel intraovarian regulator of follicular atresia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adult feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cocaine- and amphetamine-regulated transcript protein
    Names
    cocaine and amphetamine responsive transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007820.3 → NP_001007821.1  cocaine- and amphetamine-regulated transcript protein precursor

      See identical proteins and their annotated locations for NP_001007821.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114792
      UniProtKB/Swiss-Prot
      A4FUF3, Q68RJ9
      Related
      ENSBTAP00000055162.1, ENSBTAT00000064119.2
      Conserved Domains (1) summary
      pfam06373
      Location:48 → 116
      CART; Cocaine and amphetamine regulated transcript protein (CART)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9865310..9868125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981232.2 → XP_024837000.1  cocaine- and amphetamine-regulated transcript protein isoform X1

      UniProtKB/Swiss-Prot
      A4FUF3, Q68RJ9
      Conserved Domains (1) summary
      pfam06373
      Location:48 → 116
      CART; Cocaine and amphetamine regulated transcript protein (CART)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68RJ9.1 GenPept UniProtKB/Swiss-Prot:Q68RJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials