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    HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 615386, updated on 30-Jan-2025

    Summary

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    Official Symbol
    HPS4provided by VGNC
    Official Full Name
    HPS4 biogenesis of lysosomal organelles complex 3 subunit 2provided by VGNC
    Primary source
    VGNC:VGNC:29945
    See related
    EnsemblRapid:ENSBTAG00070021060
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HPS4 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (66113230..66140564, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene SRR1 domain containing Neighboring gene tuftelin interacting protein 11 Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene uncharacterized LOC132342639

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-3 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hermansky-Pudlak syndrome 4 protein; BLOC-3 complex member HPS4
    Names
    Hermansky-Pudlak syndrome 4 homolog
    light ear protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66113230..66140564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015475566.3 → XP_015331052.1  BLOC-3 complex member HPS4

      UniProtKB/TrEMBL
      A0AAA9SMM9, E1BLQ1
      Related
      ENSBTAP00070028483.1, ENSBTAT00070047604.1
      Conserved Domains (1) summary
      PRK14086
      Location:295 → 515
      dnaA; chromosomal replication initiation protein; Provisional

    2. XM_005218093.5 → XP_005218150.1  BLOC-3 complex member HPS4

      See identical proteins and their annotated locations for XP_005218150.1

      UniProtKB/TrEMBL
      A0AAA9SMM9, E1BLQ1
      Conserved Domains (1) summary
      PRK14086
      Location:295 → 515
      dnaA; chromosomal replication initiation protein; Provisional

    3. XM_059876426.1 → XP_059732409.1  BLOC-3 complex member HPS4

      UniProtKB/TrEMBL
      A0AAA9SMM9, E1BLQ1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001076368.2: Suppressed sequence

      Description
      NM_001076368.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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