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    CG15533 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15533provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039768
    Locus tag
    Dmel_CG15533
    See related
    AllianceGenome:FB:FBgn0039768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aSMase; Dmel\CG15533
    Summary
    Predicted to enable acid sphingomyelin phosphodiesterase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15533 in Genome Data Viewer
    Location:
    99F4-99F4; 3-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30428820..30431362)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26254542..26257084)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
    2. ATF4 Responds to Metabolic Stress in Drosophila. Ok S, et al. Front Biosci (Landmark Ed), 2023 Dec 26. PMID 38179767
    3. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
    4. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article
    5. Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster. Zhang J, et al. J Exp Biol, 2011 Dec 1. PMID 22071194

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid sphingomyelin phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15533-PA
    acid sphingomyelinase
    NP_651791.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30428820..30431362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143534.3 → NP_651791.2  uncharacterized protein Dmel_CG15533 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651791.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZA5, Q9VA78
      Related
      FBpp0084990
      Conserved Domains (3) summary
      smart00741
      Location:99 → 183
      SapB; Saposin (B) Domains
      cd00842
      Location:221 → 517
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:274 → 483
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZA5 Q8SZA5
    Q9VA78 Q9VA78

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