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    CYB5R4 cytochrome b5 reductase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 533608, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CYB5R4provided by VGNC
    Official Full Name
    cytochrome b5 reductase 4provided by VGNC
    Primary source
    VGNC:VGNC:50264
    See related
    Ensembl:ENSBTAG00000013591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See CYB5R4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (65426517..65543569, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101907581 Neighboring gene centrosomal protein 162 Neighboring gene melanocortin 2 receptor accessory protein 2 Neighboring gene ADP-ribosylation factor-like protein 6-interacting protein 1 Neighboring gene ripply transcriptional repressor 2 Neighboring gene histone H2B type 2-E-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC134229

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome b5 reductase 4
    Names
    b5+b5R
    cb5/cb5R
    flavohemoprotein b5/b5R
    NP_001033248.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038159.1 → NP_001033248.1  cytochrome b5 reductase 4

      See identical proteins and their annotated locations for NP_001033248.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109569
      UniProtKB/Swiss-Prot
      Q32LH7
      UniProtKB/TrEMBL
      A0A3Q1M485
      Related
      ENSBTAP00000067057.1, ENSBTAT00000084559.2
      Conserved Domains (3) summary
      cd06183
      Location:277 → 518
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      cd06490
      Location:169 → 255
      p23_NCB5OR; p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining ...
      pfam00173
      Location:56 → 128
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65426517..65543569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32LH7.1 GenPept UniProtKB/Swiss-Prot:Q32LH7

    Gene LinkOut

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