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    STK4 serine/threonine kinase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 514886, updated on 30-Jan-2025

    Summary

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    Official Symbol
    STK4provided by VGNC
    Official Full Name
    serine/threonine kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:35401
    See related
    BGD:BT29079; EnsemblRapid:ENSBTAG00070017960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See STK4 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (73371427..73461845)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene potassium voltage-gated channel modifier subfamily S member 1 Neighboring gene WAP four-disulfide core domain 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 4
    Names
    MST-1
    STE20-like kinase MST1
    mammalian STE20-like protein kinase 1
    NP_001015602.1
    XP_059748556.1
    XP_059748557.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015602.1 → NP_001015602.1  serine/threonine-protein kinase 4

      Status: PROVISIONAL

      Source sequence(s)
      BT020904
      UniProtKB/Swiss-Prot
      Q2KI66, Q5E9L6
      UniProtKB/TrEMBL
      A0A3Q1M7K8
      Related
      ENSBTAP00070024051.1, ENSBTAT00070040519.1
      Conserved Domains (2) summary
      cd06612
      Location:26 → 281
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      pfam11629
      Location:433 → 480
      Mst1_SARAH; C terminal SARAH domain of Mst1

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73371427..73461845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892574.1 → XP_059748557.1  serine/threonine-protein kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LJM2
      Related
      ENSBTAP00070024024.1, ENSBTAT00070040492.1

    2. XM_059892573.1 → XP_059748556.1  serine/threonine-protein kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SX12
      Related
      ENSBTAP00070024039.1, ENSBTAT00070040507.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9L6.1 GenPept UniProtKB/Swiss-Prot:Q5E9L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.