UBA7 ubiquitin like modifier activating enzyme 7 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: UBA7provided by VGNC
Official Full Name: ubiquitin like modifier activating enzyme 7provided by VGNC
Primary source: VGNC:VGNC:36566
See related: BGD:BT29830; Ensembl:ENSBTAG00000012335
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: UBE1L
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (50421018..50430082)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ISG15, UBE1l and UBCH8 genes are significantly upregulated in the artificially inseminated pregnant cows.
Title: Expression of interferon-stimulated gene ISG15 and ubiquitination enzymes is upregulated in peripheral blood monocyte during early pregnancy in dairy cattle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ISG15 activating enzyme activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ISG15-protein conjugation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012284.1 → NP_001012284.1 ubiquitin-like modifier-activating enzyme 7

Status: PROVISIONAL

Source sequence(s)

AY597816

UniProtKB/TrEMBL

F6Q4D3, Q5GF34

Related

ENSBTAP00000016365.4, ENSBTAT00000016365.5

Conserved Domains (4) summary

cd01491
Location:14 → 398

Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

TIGR01408
Location:10 → 997

Ube1; ubiquitin-activating enzyme E1

pfam16191
Location:263 → 325

E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

cl22428
Location:433 → 959

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...