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    MACROH2A1 macroH2A.1 histone [ Bos taurus (domestic cattle) ]

    Gene ID: 532990, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MACROH2A1provided by VGNC
    Official Full Name
    macroH2A.1 histoneprovided by VGNC
    Primary source
    VGNC:VGNC:83608
    See related
    BGD:BT26863; Ensembl:ENSBTAG00000016105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    H2AFY
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See MACROH2A1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (46800652..46882553, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene paired like homeodomain 1 Neighboring gene uncharacterized LOC104969177 Neighboring gene uncharacterized LOC132345749 Neighboring gene TIFA inhibitor Neighboring gene neurogenin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC137823

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    core histone macro-H2A.1
    Names
    H2A histone family, member Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046340.1 → NP_001039805.1  core histone macro-H2A.1

      See identical proteins and their annotated locations for NP_001039805.1

      Status: PROVISIONAL

      Source sequence(s)
      BC113287
      UniProtKB/TrEMBL
      A0AAA9TQP9, F1N509, Q2HJ65
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:177 → 363
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      46800652..46882553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024994341.2 → XP_024850109.1  core histone macro-H2A.1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TQP9, F1N509, Q2HJ65
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:177 → 363
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    2. XM_005209377.3 → XP_005209434.1  core histone macro-H2A.1 isoform X1

      See identical proteins and their annotated locations for XP_005209434.1

      UniProtKB/TrEMBL
      A0AAA9TLZ5, A0AAA9TQP9
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:178 → 364
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    3. XM_005209379.3 → XP_005209436.1  core histone macro-H2A.1 isoform X4

      See identical proteins and their annotated locations for XP_005209436.1

      UniProtKB/TrEMBL
      A0AAF6DLJ4
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:177 → 360
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    4. XM_005209378.3 → XP_005209435.1  core histone macro-H2A.1 isoform X3

      See identical proteins and their annotated locations for XP_005209435.1

      UniProtKB/TrEMBL
      A0A3Q1LZ47
      Related
      ENSBTAP00000060958.2, ENSBTAT00000085829.2
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:178 → 361
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    5. XM_005209376.3 → XP_005209433.1  core histone macro-H2A.1 isoform X1

      See identical proteins and their annotated locations for XP_005209433.1

      UniProtKB/TrEMBL
      A0AAA9TLZ5, A0AAA9TQP9
      Related
      ENSBTAP00000098266.1, ENSBTAT00000108319.1
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cd02904
      Location:178 → 364
      Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    6. XM_024994342.2 → XP_024850110.1  core histone macro-H2A.1 isoform X5

      UniProtKB/TrEMBL
      A0AAF6DLJ4
      Related
      ENSBTAP00000021436.5, ENSBTAT00000021436.6
      Conserved Domains (2) summary
      cd00074
      Location:5 → 117
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
      cl00019
      Location:178 → 320
      Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
    Nucleotide Protein Strain
    Heading Accession and Version

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