HSP90AA1 heat shock protein 90 alpha family class A member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: HSP90AA1provided by VGNC
Official Full Name: heat shock protein 90 alpha family class A member 1provided by VGNC
Primary source: VGNC:VGNC:53940
See related: BGD:BT10065; Ensembl:ENSBTAG00000006270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HSPCA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (66939612..66944979, complement)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association analysis of HSP90AA1 polymorphism with thermotolerance in tropically adapted Indian crossbred cattle.
Title: Association analysis of HSP90AA1 polymorphism with thermotolerance in tropically adapted Indian crossbred cattle.
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Title: The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Inhibition of HSP90AA1 induces abnormalities in bovine oocyte maturation and embryonic development.
Title: Inhibition of HSP90AA1 induces abnormalities in bovine oocyte maturation and embryonic development.
Characterization of a putative ribosome binding site at the 5' untranslated region of bovine heat shock protein 90.
Title: Characterization of a putative ribosome binding site at the 5' untranslated region of bovine heat shock protein 90.
there was an association between genetic variations in the Hsp90AA1 and thermoresistance.
Title: Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of HSP90AA1 and PGES (prostaglandin-E synthase).
Title: Summer heat stress affects prostaglandin synthesis in the bovine oviduct.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90(HSP90).
Title: Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH75563 (e-PCR)
- UniSTS:92017

Hspca (e-PCR), detects polymorphism
- UniSTS:461999

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in myelin sheath	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock protein HSP 90-alpha

Names: heat shock 90 kDa protein 1; heat shock 90kD protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1

NP_001012688.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.