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    ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 532663, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ENPP2provided by VGNC
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 2provided by VGNC
    Primary source
    VGNC:VGNC:28505
    See related
    Ensembl:ENSBTAG00000013165
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ENPP2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (80982686..81118870, complement)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100335514 Neighboring gene zinc finger AN1-type containing 1 Neighboring gene solute carrier family 10 member 5 Neighboring gene inositol monophosphatase 1 Neighboring gene microRNA mir-2285n-6 Neighboring gene uncharacterized LOC104974144 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene DNA replication and sister chromatid cohesion 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Which bovine endometrial cells are the source of and target for lysophosphatidic acid? Boruszewska D, et al. Reprod Biol, 2013 Mar. PMID 23522079
    2. Cyclic phosphatidic acid is produced by autotaxin in blood. Tsuda S, et al. J Biol Chem, 2006 Sep 8. PMID 16837466
    3. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. Umezu-Goto M, et al. J Cell Biol, 2002 Jul 22. PMID 12119361, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression is greater in epithelial cells than in stromal cells of the endometrium
      Title: Which bovine endometrial cells are the source of and target for lysophosphatidic acid?
    2. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
      Title: Cyclic phosphatidic acid is produced by autotaxin in blood.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC142749

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables alkylglycerophosphoethanolamine phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphodiesterase I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in estrous cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylcholine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    autotaxin
    Names
    E-NPP 2
    ectonucleotide pyrophosphatase/phosphodiesterase family member 2
    extracellular lysophospholipase D
    lysoPLD
    NP_001073762.1
    XP_010810523.1
    XP_015330019.1
    XP_015330020.1
    XP_015330021.1
    XP_015330022.1
    XP_024857378.1
    XP_024857380.2
    XP_024857381.1
    XP_024857382.2
    XP_024857383.1
    XP_024857384.2
    XP_024857385.1
    XP_024857386.1
    XP_024857388.2
    XP_059749269.1
    XP_059749270.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080293.1 → NP_001073762.1  autotaxin precursor

      See identical proteins and their annotated locations for NP_001073762.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126631
      UniProtKB/Swiss-Prot
      A1A4K5
      UniProtKB/TrEMBL
      A0A3Q1M2M4
      Related
      ENSBTAP00000059889.2, ENSBTAT00000076817.2
      Conserved Domains (4) summary
      smart00201
      Location:55 → 98
      SO; Somatomedin B -like domains
      smart00477
      Location:640 → 870
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:166 → 478
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:164 → 518
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      80982686..81118870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015474534.3 → XP_015330020.1  autotaxin isoform X3

      UniProtKB/TrEMBL
      A0AAF6ZCL7
      Conserved Domains (4) summary
      smart00201
      Location:122 → 165
      SO; Somatomedin B -like domains
      smart00477
      Location:734 → 964
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:233 → 597
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:231 → 637
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. XM_015474533.3 → XP_015330019.1  autotaxin isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZCL7
      Conserved Domains (4) summary
      smart00201
      Location:122 → 165
      SO; Somatomedin B -like domains
      smart00477
      Location:759 → 989
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:233 → 597
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:231 → 637
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. XM_015474536.3 → XP_015330022.1  autotaxin isoform X9

      UniProtKB/TrEMBL
      A0A3Q1LYS8, A0A3Q1M2M4
      Related
      ENSBTAP00000065936.2, ENSBTAT00000078741.2
      Conserved Domains (4) summary
      smart00201
      Location:122 → 165
      SO; Somatomedin B -like domains
      smart00477
      Location:682 → 912
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:233 → 545
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:231 → 585
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    4. XM_015474535.3 → XP_015330021.1  autotaxin isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M2M4
      Conserved Domains (4) summary
      smart00201
      Location:122 → 165
      SO; Somatomedin B -like domains
      smart00477
      Location:707 → 937
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:233 → 545
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:231 → 585
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    5. XM_059893287.1 → XP_059749270.1  autotaxin isoform X16

      UniProtKB/TrEMBL
      A0A3Q1M2M4

    6. XM_025001617.2 → XP_024857385.1  autotaxin isoform X14

      UniProtKB/TrEMBL
      A0A3Q1M2M4
      Conserved Domains (3) summary
      smart00201
      Location:45 → 88
      SO; Somatomedin B -like domains
      smart00477
      Location:630 → 860
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:156 → 468
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

    7. XM_059893286.1 → XP_059749269.1  autotaxin isoform X12

      UniProtKB/TrEMBL
      A0AAF6ZCL7

    8. XM_025001613.2 → XP_024857381.1  autotaxin isoform X8

      UniProtKB/TrEMBL
      A0AAF6ZCL7
      Conserved Domains (3) summary
      smart00201
      Location:45 → 88
      SO; Somatomedin B -like domains
      smart00477
      Location:682 → 912
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:156 → 520
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

    9. XM_025001620.2 → XP_024857388.2  autotaxin isoform X13

      UniProtKB/TrEMBL
      A0AAA9TBJ2
      Related
      ENSBTAP00000094206.1, ENSBTAT00000099386.1

    10. XM_025001616.2 → XP_024857384.2  autotaxin isoform X10

      UniProtKB/TrEMBL
      A0AAA9RX78
      Related
      ENSBTAP00000075789.1, ENSBTAT00000121432.1

    11. XM_025001614.2 → XP_024857382.2  autotaxin isoform X6

      UniProtKB/TrEMBL
      A0AAA9TBJ2

    12. XM_025001612.2 → XP_024857380.2  autotaxin isoform X4

      UniProtKB/TrEMBL
      A0AAA9RX78

    13. XM_010812221.4 → XP_010810523.1  autotaxin isoform X7

      UniProtKB/TrEMBL
      A0AAF6ZCL7
      Related
      ENSBTAP00000036974.5, ENSBTAT00000037135.6
      Conserved Domains (4) summary
      smart00201
      Location:55 → 98
      SO; Somatomedin B -like domains
      smart00477
      Location:692 → 922
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:166 → 530
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:164 → 570
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    14. XM_025001618.2 → XP_024857386.1  autotaxin isoform X15

      UniProtKB/TrEMBL
      A0A3Q1M2M4
      Conserved Domains (3) summary
      smart00201
      Location:55 → 98
      SO; Somatomedin B -like domains
      smart00477
      Location:615 → 845
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:166 → 478
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

    15. XM_025001615.1 → XP_024857383.1  autotaxin isoform X11

      UniProtKB/TrEMBL
      A0A3Q1M2M4, A0AAA9T0V7
      Related
      ENSBTAP00000089278.1, ENSBTAT00000107333.1
      Conserved Domains (3) summary
      smart00201
      Location:58 → 101
      SO; Somatomedin B -like domains
      smart00477
      Location:618 → 848
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:169 → 481
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

    16. XM_025001610.2 → XP_024857378.1  autotaxin isoform X2

      UniProtKB/TrEMBL
      A0AAF6ZCL7
      Conserved Domains (3) summary
      smart00201
      Location:19 → 62
      SO; Somatomedin B -like domains
      smart00477
      Location:656 → 886
      NUC; DNA/RNA non-specific endonuclease
      pfam01663
      Location:130 → 494
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A4K5.1 GenPept UniProtKB/Swiss-Prot:A1A4K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials